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dc.contributor.author Wesolowski, Janusz
dc.contributor.author Alzogaray, Vanina Andrea
dc.contributor.author Reyelt, Jan
dc.contributor.author Unger, Mandy
dc.contributor.author Juarez, Karla
dc.contributor.author Urrutia, Mariela
dc.contributor.author Cauerhff, Ana
dc.contributor.author Danquah, Welbeck
dc.contributor.author Rissiek, Björn
dc.contributor.author Scheuplein, Felix
dc.contributor.author Schwarz, Nicole
dc.contributor.author Adriouch, Sahil
dc.contributor.author Boyer, Olivier
dc.contributor.author Seman, Michel
dc.contributor.author Licea, Alexei
dc.contributor.author Serreze, David V.
dc.contributor.author Goldbaum, Fernando Alberto
dc.contributor.author Haag, Friedrich
dc.contributor.author Koch Nolte, Friedrich
dc.date.available 2018-02-20T20:19:10Z
dc.date.issued 2009-08
dc.identifier.citation Wesolowski, Janusz; Alzogaray, Vanina Andrea; Reyelt, Jan; Unger, Mandy; Juarez, Karla; et al.; Single domain antibodies: Promising experimental and therapeutic tools in infection and immunity; Springer; Medical Microbiology and Immunology; 198; 3; 8-2009; 157-174
dc.identifier.issn 0300-8584
dc.identifier.uri http://hdl.handle.net/11336/36849
dc.description.abstract Antibodies are important tools for experimental research and medical applications. Most antibodies are composed of two heavy and two light chains. Both chains contribute to the antigen-binding site which is usually flat or concave. In addition to these conventional antibodies, llamas, other camelids, and sharks also produce antibodies composed only of heavy chains. The antigen-binding site of these unusual heavy chain antibodies (hcAbs) is formed only by a single domain, designated VHH in camelid hcAbs and VNAR in shark hcAbs. VHH and VNAR are easily produced as recombinant proteins, designated single domain antibodies (sdAbs) or nanobodies. The CDR3 region of these sdAbs possesses the extraordinary capacity to form long fingerlike extensions that can extend into cavities on antigens, e.g., the active site crevice of enzymes. Other advantageous features of nanobodies include their small size, high solubility, thermal stability, refolding capacity, and good tissue penetration in vivo. Here we review the results of several recent proof-of-principle studies that open the exciting perspective of using sdAbs for modulating immune functions and for targeting toxins and microbes.
dc.format application/pdf
dc.language.iso eng
dc.publisher Springer
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject ENZYME INHIBITORS
dc.subject NANOBODY
dc.subject RECOMBINANT ANTIBODIES
dc.subject SINGLE DOMAIN ANTIBODIES
dc.subject VHH
dc.subject VIRUS NEUTRALIZATION
dc.title Single domain antibodies: Promising experimental and therapeutic tools in infection and immunity
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-09-29T19:45:11Z
dc.journal.volume 198
dc.journal.number 3
dc.journal.pagination 157-174
dc.journal.pais Alemania
dc.description.fil Fil: Wesolowski, Janusz. Universitatsklinikum Hamburg-eppendorf Und Medizinische Fakultat; Alemania
dc.description.fil Fil: Alzogaray, Vanina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
dc.description.fil Fil: Reyelt, Jan. Universitatsklinikum Hamburg-eppendorf Und Medizinische Fakultat; Alemania
dc.description.fil Fil: Unger, Mandy. Universitatsklinikum Hamburg-eppendorf Und Medizinische Fakultat; Alemania
dc.description.fil Fil: Juarez, Karla. Universitatsklinikum Hamburg-eppendorf Und Medizinische Fakultat; Alemania. Centro de Investigacion Cientifica y de Educacion Superior de Ensenada; México
dc.description.fil Fil: Urrutia, Mariela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
dc.description.fil Fil: Cauerhff, Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
dc.description.fil Fil: Danquah, Welbeck. Universitatsklinikum Hamburg-eppendorf Und Medizinische Fakultat; Alemania
dc.description.fil Fil: Rissiek, Björn. Universitatsklinikum Hamburg-eppendorf Und Medizinische Fakultat; Alemania
dc.description.fil Fil: Scheuplein, Felix. Universitatsklinikum Hamburg-eppendorf Und Medizinische Fakultat; Alemania
dc.description.fil Fil: Schwarz, Nicole. Universitatsklinikum Hamburg-eppendorf Und Medizinische Fakultat; Alemania
dc.description.fil Fil: Adriouch, Sahil. Chu Hopitaux de Rouen; Francia
dc.description.fil Fil: Boyer, Olivier. Chu Hopitaux de Rouen; Francia
dc.description.fil Fil: Seman, Michel. Chu Hopitaux de Rouen; Francia
dc.description.fil Fil: Licea, Alexei. Centro de Investigacion Cientifica y de Educacion Superior de Ensenada; México
dc.description.fil Fil: Serreze, David V.. Jackson Laboratory; Estados Unidos
dc.description.fil Fil: Goldbaum, Fernando Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
dc.description.fil Fil: Haag, Friedrich. Universitatsklinikum Hamburg-eppendorf Und Medizinische Fakultat; Alemania
dc.description.fil Fil: Koch Nolte, Friedrich. Universitatsklinikum Hamburg-eppendorf Und Medizinische Fakultat; Alemania
dc.journal.title Medical Microbiology and Immunology
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00430-009-0116-7
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00430-009-0116-7


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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)