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dc.contributor.author
Wesolowski, Janusz
dc.contributor.author
Alzogaray, Vanina Andrea
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Reyelt, Jan
dc.contributor.author
Unger, Mandy
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Juarez, Karla
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Urrutia, Mariela
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Cauerhff, Ana
dc.contributor.author
Danquah, Welbeck
dc.contributor.author
Rissiek, Björn
dc.contributor.author
Scheuplein, Felix
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Schwarz, Nicole
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Adriouch, Sahil
dc.contributor.author
Boyer, Olivier
dc.contributor.author
Seman, Michel
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Licea, Alexei
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Serreze, David V.
dc.contributor.author
Goldbaum, Fernando Alberto
dc.contributor.author
Haag, Friedrich
dc.contributor.author
Koch Nolte, Friedrich
dc.date.available
2018-02-20T20:19:10Z
dc.date.issued
2009-08
dc.identifier.citation
Wesolowski, Janusz; Alzogaray, Vanina Andrea; Reyelt, Jan; Unger, Mandy; Juarez, Karla; et al.; Single domain antibodies: Promising experimental and therapeutic tools in infection and immunity; Springer; Medical Microbiology and Immunology; 198; 3; 8-2009; 157-174
dc.identifier.issn
0300-8584
dc.identifier.uri
http://hdl.handle.net/11336/36849
dc.description.abstract
Antibodies are important tools for experimental research and medical applications. Most antibodies are composed of two heavy and two light chains. Both chains contribute to the antigen-binding site which is usually flat or concave. In addition to these conventional antibodies, llamas, other camelids, and sharks also produce antibodies composed only of heavy chains. The antigen-binding site of these unusual heavy chain antibodies (hcAbs) is formed only by a single domain, designated VHH in camelid hcAbs and VNAR in shark hcAbs. VHH and VNAR are easily produced as recombinant proteins, designated single domain antibodies (sdAbs) or nanobodies. The CDR3 region of these sdAbs possesses the extraordinary capacity to form long fingerlike extensions that can extend into cavities on antigens, e.g., the active site crevice of enzymes. Other advantageous features of nanobodies include their small size, high solubility, thermal stability, refolding capacity, and good tissue penetration in vivo. Here we review the results of several recent proof-of-principle studies that open the exciting perspective of using sdAbs for modulating immune functions and for targeting toxins and microbes.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Enzyme Inhibitors
dc.subject
Nanobody
dc.subject
Recombinant Antibodies
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Single Domain Antibodies
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Vhh
dc.subject
Virus Neutralization
dc.title
Single domain antibodies: Promising experimental and therapeutic tools in infection and immunity
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-09-29T19:45:11Z
dc.journal.volume
198
dc.journal.number
3
dc.journal.pagination
157-174
dc.journal.pais
Alemania
dc.description.fil
Fil: Wesolowski, Janusz. Universitatsklinikum Hamburg-eppendorf Und Medizinische Fakultat; Alemania
dc.description.fil
Fil: Alzogaray, Vanina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
dc.description.fil
Fil: Reyelt, Jan. Universitatsklinikum Hamburg-eppendorf Und Medizinische Fakultat; Alemania
dc.description.fil
Fil: Unger, Mandy. Universitatsklinikum Hamburg-eppendorf Und Medizinische Fakultat; Alemania
dc.description.fil
Fil: Juarez, Karla. Universitatsklinikum Hamburg-eppendorf Und Medizinische Fakultat; Alemania. Centro de Investigacion Cientifica y de Educacion Superior de Ensenada; México
dc.description.fil
Fil: Urrutia, Mariela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
dc.description.fil
Fil: Cauerhff, Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
dc.description.fil
Fil: Danquah, Welbeck. Universitatsklinikum Hamburg-eppendorf Und Medizinische Fakultat; Alemania
dc.description.fil
Fil: Rissiek, Björn. Universitatsklinikum Hamburg-eppendorf Und Medizinische Fakultat; Alemania
dc.description.fil
Fil: Scheuplein, Felix. Universitatsklinikum Hamburg-eppendorf Und Medizinische Fakultat; Alemania
dc.description.fil
Fil: Schwarz, Nicole. Universitatsklinikum Hamburg-eppendorf Und Medizinische Fakultat; Alemania
dc.description.fil
Fil: Adriouch, Sahil. Chu Hopitaux de Rouen; Francia
dc.description.fil
Fil: Boyer, Olivier. Chu Hopitaux de Rouen; Francia
dc.description.fil
Fil: Seman, Michel. Chu Hopitaux de Rouen; Francia
dc.description.fil
Fil: Licea, Alexei. Centro de Investigacion Cientifica y de Educacion Superior de Ensenada; México
dc.description.fil
Fil: Serreze, David V.. Jackson Laboratory; Estados Unidos
dc.description.fil
Fil: Goldbaum, Fernando Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
dc.description.fil
Fil: Haag, Friedrich. Universitatsklinikum Hamburg-eppendorf Und Medizinische Fakultat; Alemania
dc.description.fil
Fil: Koch Nolte, Friedrich. Universitatsklinikum Hamburg-eppendorf Und Medizinische Fakultat; Alemania
dc.journal.title
Medical Microbiology and Immunology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00430-009-0116-7
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00430-009-0116-7


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