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dc.contributor.author
Rachid, Mirta Maria
dc.contributor.author
Matar, Chantal
dc.contributor.author
Duarte, Jairo
dc.contributor.author
Perdigon, Gabriela del Valle
dc.date.available
2018-02-19T17:53:55Z
dc.date.issued
2006-07
dc.identifier.citation
Rachid, Mirta Maria; Matar, Chantal; Duarte, Jairo; Perdigon, Gabriela del Valle; Effect of milk fermented with a Lactobacillus helveticus R389(+) proteolytic strain on the immune system and on the growth of 4T1 breast cancer cells in mice; Wiley Blackwell Publishing, Inc; Fems Immunology And Medical Microbiology; 47; 2; 7-2006; 242-253
dc.identifier.issn
0928-8244
dc.identifier.uri
http://hdl.handle.net/11336/36724
dc.description.abstract
Previous studies on a murine model have demonstrated that the administration of Lactobacillus helveticus and Lactobacillus casei inhibits the development of fibrosarcoma and colon carcinoma, respectively. The aim of this work was to study the beneficial effects of the consumption of milk fermented by L. helveticus on a murine model for mammary carcinoma. Female BALB/c mice were challenged by a single subcutaneous injection of tumoral cells (American Type Culture Collection 4T1) in the left mammary gland. Prior to tumour injection, mice were fed for two, five or seven consecutive days with fermented milk. The following factors were monitored for 2 months: rate of tumour development, histological studies, apoptosis, phagocytic index, peritoneal macrophages, determination of β-glucuronidase enzyme in peritoneal macrophages, determination of γ-interferon (INFγ) and tumour necrosis factor-α (TNF-α) in blood serum, determination of CD4+, CD8+, interleukin-6 (IL-6), IL-10, TNF-α and INFγ by immunoperoxidase, and measurement of β-glucuronidase activity in intestinal fluid. The administration of L. helveticus delayed the development of the tumour in all cases, a 2- or 7-day feeding period being most effective. This work demonstrates that milk fermented with L. helveticus decreases the growth rate of mammary tumours. The effect was mediated by increased apoptosis and decreased production of pro-inflammatory cytokines, in particular IL-6, implicated in oestrogen synthesis.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Breast Cancer
dc.subject
Fermented Milk
dc.subject
Proteolytic Strain
dc.subject.classification
Inmunología
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Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Effect of milk fermented with a Lactobacillus helveticus R389(+) proteolytic strain on the immune system and on the growth of 4T1 breast cancer cells in mice
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-08-24T18:59:02Z
dc.journal.volume
47
dc.journal.number
2
dc.journal.pagination
242-253
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Rachid, Mirta Maria. Universite de Moncton; Canadá. Universidad Nacional de Tucumán; Argentina
dc.description.fil
Fil: Matar, Chantal. Universite de Moncton; Canadá
dc.description.fil
Fil: Duarte, Jairo. Universite de Moncton; Canadá
dc.description.fil
Fil: Perdigon, Gabriela del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina. Universidad Nacional de Tucumán; Argentina
dc.journal.title
Fems Immunology And Medical Microbiology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/j.1574-695X.2006.00088.x
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/femspd/article/47/2/242/548958


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