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Artículo

Enhanced chemoprophylactic and clinical efficacy of albendazole formulated as solid dispersions in experimental cystic echinococcosis

Pensel, Patricia EugeniaIcon ; Castro, Silvana Luisa; Allemandi, Daniel AlbertoIcon ; Sanchez Bruni, Sergio FabianIcon ; Palma, Santiago DanielIcon ; Elissondo, María CelinaIcon
Fecha de publicación: 04/2014
Editorial: Elsevier Science
Revista: Veterinary Parasitology
ISSN: 0304-4017
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Enfermedades Infecciosas

Resumen

Cystic echinococcosis is a chronic, complex, and still neglected disease. Although albendazole has demonstrated efficacy, only about one-third of patients experience complete remission or cure and 30–50% of treated patients develop some evidence of a therapeutic response. Different strategies have been developed in order to improve the albendazole water solubility and dissolution rate. The aim of the current work was to investigate the chemoprophylactic and clinical efficacy of an albendazole:poloxamer 188 solid dispersion formulation on mice infected with Echinococcus granulosus metacestodes. Albendazole formulated as solid dispersion had greater chemoprophylactic and clinical efficacy than albendazole alone. The improved in therapeutic efficacy could be a consequence of the increase in the systemic availability of albendazole sulfoxide. The work reported here demonstrates that in vivo treatment with albendazole:poloxamer 188 impairs the development of the hydatid cysts. This new pharmacotechnically based strategy could be a suitable alternative for treating cystic echinococcosis in humans.
Palabras clave: Cystic Echinococcosis , Echinococcus Granulosus , Albendazole , Solid Dispersions
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/34589
DOI: http://dx.doi.org/10.1016/j.vetpar.2014.01.027
URL: https://www.sciencedirect.com/science/article/pii/S0304401714000697
Colecciones
Articulos(CCT - MAR DEL PLATA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - MAR DEL PLATA
Articulos(CIVETAN)
Articulos de CENTRO DE INVESTIGACION VETERINARIA DE TANDIL
Citación
Pensel, Patricia Eugenia; Castro, Silvana Luisa; Allemandi, Daniel Alberto; Sanchez Bruni, Sergio Fabian; Palma, Santiago Daniel; et al.; Enhanced chemoprophylactic and clinical efficacy of albendazole formulated as solid dispersions in experimental cystic echinococcosis; Elsevier Science; Veterinary Parasitology; 203; 1-2; 4-2014; 80-86
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