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Artículo

Assessing the energetic costs and trade-offs of a PHA-induced inflammation in the subterranean rodent Ctenomys talarum: Immune response in growing tuco-tucos

Cutrera, Ana PaulaIcon ; Luna, FacundoIcon ; Merlo, JulietaIcon ; Baldo, María BelénIcon ; Zenuto, Roxana RitaIcon
Fecha de publicación: 05/2014
Editorial: Elsevier Science Inc
Revista: Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology
ISSN: 1095-6433
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Biológicas

Resumen

A traditional approach used to assess whether immune defense is costly is to explore the existence of trade-offs between immunity and other functions; however, quantitative studies of the energetic costs associated with the activation of the immune system are scarce. We assessed the magnitude of a PHA-triggered immune response and the associated energetic costs in 60-day old Ctenomys talarum. We expected that the magnitude of the macroscopic inflammatory response to PHA is lower in young tuco-tucos compared with that of adults, given the allocation of substantial energy to growth, and that the magnitude of the inflammation is lower in male pups compared to females, due to the higher investment in growth of the larger sex. Concomitantly, we expected that the pups challenged with PHA show an increase in oxygen consumption compared to control animals and that a positive association exists between magnitude of the PHA-induced inflammation and oxygen consumption. Contrary to what was expected, young tuco-tucos mounted a higher inflammatory response compared with adults and there were no differences in the magnitude of this response between sexes. The inflammatory response induced by a PHA injection did not represent a significant energetic cost for young tuco-tucos. There were no differences in oxygen consumption between PHA-injected and control animals, and tuco-tucos that mounted a higher inflammatory response to PHA did not show higher oxygen consumption. Energy expenditure, however, is not the only physiological cost involved in trade-offs between immune response and various functions of the organism, and other currencies are discussed.
Palabras clave: Growth , Maturation , Cell-Mediated , Innate , Subterranean , Pha
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/34435
DOI: http://dx.doi.org/10.1016/j.cbpa.2014.04.001
URL: https://www.sciencedirect.com/science/article/pii/S1095643314000737
Colecciones
Articulos(IIMYC)
Articulos de INSTITUTO DE INVESTIGACIONES MARINAS Y COSTERAS
Citación
Cutrera, Ana Paula; Luna, Facundo; Merlo, Julieta; Baldo, María Belén; Zenuto, Roxana Rita; Assessing the energetic costs and trade-offs of a PHA-induced inflammation in the subterranean rodent Ctenomys talarum: Immune response in growing tuco-tucos; Elsevier Science Inc; Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology; 174; 5-2014; 23-28
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