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dc.contributor.author
Sparacino, Javier
dc.contributor.author
Farías, María Gimena
dc.contributor.author
Lamberti, Pedro Walter
dc.date.available
2018-01-18T18:05:53Z
dc.date.issued
2014-02
dc.identifier.citation
Sparacino, Javier; Farías, María Gimena; Lamberti, Pedro Walter; Effect of the microtubule-associated protein tau on dynamics of single-headed motor proteins KIF1A; American Physical Society; Physical Review E: Statistical, Nonlinear and Soft Matter Physics; 89; 2; 2-2014; 227141-227148
dc.identifier.issn
1539-3755
dc.identifier.uri
http://hdl.handle.net/11336/33806
dc.description.abstract
Intracellular transport based on molecular motors and its regulation are crucial to the functioning of cells. Filamentary tracks of the cells are abundantly decorated with nonmotile microtubule-associated proteins, such as tau. Motivated by experiments on kinesin-tau interactions [Dixit et al., Science 319, 1086 (2008)] we developed a stochastic model of interacting single-headed motor proteins KIF1A that also takes into account the interactions between motor proteins and tau molecules. Our model reproduces experimental observations and predicts significant effects of tau on bound time and run length which suggest an important role of tau in regulation of kinesin-based transport.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Physical Society
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Motores Moleculares
dc.subject
Simulación Monte Carlo
dc.subject
Procesos Estocásticos
dc.subject
Proteínas Asociadas al Microtúbulo
dc.subject.classification
Astronomía
dc.subject.classification
Ciencias Físicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Effect of the microtubule-associated protein tau on dynamics of single-headed motor proteins KIF1A
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-01-17T15:15:50Z
dc.journal.volume
89
dc.journal.number
2
dc.journal.pagination
227141-227148
dc.journal.pais
Estados Unidos
dc.journal.ciudad
New York
dc.description.fil
Fil: Sparacino, Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
dc.description.fil
Fil: Farías, María Gimena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
dc.description.fil
Fil: Lamberti, Pedro Walter. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
dc.journal.title
Physical Review E: Statistical, Nonlinear and Soft Matter Physics
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1103/PhysRevE.89.022714
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://journals.aps.org/pre/abstract/10.1103/PhysRevE.89.022714


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