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dc.contributor.author Cristina, Silvia Carolina
dc.contributor.author Garcia Tornadu, Isabel Andrea
dc.contributor.author Diaz, Graciela Susana
dc.contributor.author Rubinstein, Marcelo
dc.contributor.author Low, M. J.
dc.contributor.author Becu, Damasia
dc.date.available 2017-12-28T19:46:35Z
dc.date.issued 2005-12
dc.identifier.citation Becu, Damasia; Low, M. J.; Rubinstein, Marcelo; Diaz, Graciela Susana; Garcia Tornadu, Isabel Andrea; Cristina, Silvia Carolina; et al.; Dopaminergic D2 receptor knockout mouse: an animal model of prolactinoma; Karger; Frontiers Of Hormone Research.; 35; 12-2005; 50-63
dc.identifier.issn 0301-3073
dc.identifier.uri http://hdl.handle.net/11336/31874
dc.description.abstract Dopamine receptor type 2 (D2R) knockout mice (KO) have chronic hyperprolactinemia, pituitary hyperplasia, and a moderate decrease in MSH content. They are also growth retarded evidencing an alteration in the GH-IGF-I axis. In D2R KO, lactotropes do not show dense secretory granules but degranulated cells and fewer somatotropes, gonadotropes and thyrotropes. Prolactin levels are always higher in female than in male knockouts, and in accordance, pituitary hyperplasia is observed at 8 months only in females. After 16 months of age, highly vascularized adenomas develop, especially in females. Prominent vascular channels in the hyperplastic and adenomatous pituitaries, as well as extravasated red blood cells not contained in capillaries is also a common finding. Prolactin is not the factor that enhances the hyperplastic phenotype in females while estrogen is a permissive factor. VEGF-A expression is increased in pituitaries from D2R KO. VEGF-A is expressed in follicle stellate cells. Because D2R receptors are found in lactotropes and not in follicle stellate cells, it may be inferred that a paracrine-derived factor from lactotropes is acting on follicle stellate cells to increase VEGF-A expression. VEGF-A does not induce pituitary cell proliferation, even though it enhances prolactin secretion. But it may act on adjacent endothelial cells and participate in the angiogenic process that increases the availability of different growth factors and mitogens. The D2R knockout mouse represents a unique animal model to study dopamine-resistant prolactinomas, and VEGF-A may be an alternative therapeutic target in this pathology.
dc.format application/pdf
dc.language.iso eng
dc.publisher Karger
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject DOPAMINE
dc.subject PROLACTINOMA
dc.subject VEGF
dc.subject PCNA
dc.subject.classification Inmunología
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Dopaminergic D2 receptor knockout mouse: an animal model of prolactinoma
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-12-28T13:40:00Z
dc.identifier.eissn 1662-3762
dc.journal.volume 35
dc.journal.pagination 50-63
dc.journal.pais Estados Unidos
dc.journal.ciudad New York
dc.description.fil Fil: Cristina, Silvia Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil Fil: Garcia Tornadu, Isabel Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil Fil: Diaz, Graciela Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil Fil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular ; Argentina
dc.description.fil Fil: Low, M. J.. University of Oregon; Estados Unidos
dc.description.fil Fil: Becu, Damasia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.journal.title Frontiers Of Hormone Research.
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/Abstract/94308
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1159/000094308
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/pmid/16809922
dc.conicet.fuente individual


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)