Artículo
Antifungal Terpenoids from Hyalis argentea var. latisquama
Fernandez, Lucia Raquel
; Butassi, Estefanía
; Svetaz, Laura Andrea
; Zacchino, Susana Alicia Stella; Palermo, Jorge Alejandro
; Sánchez, Marianela
Fecha de publicación:
07/2014
Editorial:
American Chemical Society
Revista:
Journal of Natural Products
ISSN:
0163-3864
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
A detailed chemical study of the aerial parts and rhizomes of Hyalis argentea var. latisquama yielded a variety of sesqui- and diterpenes. In total, 26 compounds were isolated and identified, of which four are new, namely, two ent-kaurenes (1 and 2), a diterpene lactone (3), and a lindenanolide (4). The previously reported compounds included a series of lindenanolides, guaianolides, elemanolides, and additional diterpenes. The antifungal activity of the isolated compounds was tested against Cryptococcus neoformans and Candida albicans. Among the isolated compounds, the lindenanolides were the only structural class that showed strong antifungal activity, and onoseriolide acetate (5) was the most active. On the other hand, the isolated guaianolides were only moderately active, while the diterpenes did not show significant antifungal activity.
Palabras clave:
Hyalis Argentea
,
Terpenoids
,
Chemical Study
,
Antifungal Activity
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(CCT - ROSARIO)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - ROSARIO
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - ROSARIO
Articulos(CEFOBI)
Articulos de CENTRO DE EST.FOTOSINTETICOS Y BIOQUIMICOS (I)
Articulos de CENTRO DE EST.FOTOSINTETICOS Y BIOQUIMICOS (I)
Articulos(UMYMFOR)
Articulos de UNID.MICROANAL.Y MET.FISICOS EN QUIM.ORG.(I)
Articulos de UNID.MICROANAL.Y MET.FISICOS EN QUIM.ORG.(I)
Citación
Sánchez, Marianela; Palermo, Jorge Alejandro; Zacchino, Susana Alicia Stella; Svetaz, Laura Andrea; Butassi, Estefanía; Fernandez, Lucia Raquel; et al.; Antifungal Terpenoids from Hyalis argentea var. latisquama
; American Chemical Society; Journal of Natural Products; 77; 7; 7-2014; 1579-1585
Compartir
Altmétricas