Artículo

A facile and convenient sequential homobimetallic catalytic approach towards β-methylstyrenes. A one-pot Stille cross-coupling/isomerization strategy

Simonetti, Sebastián OsvaldoIcon ; Larghi, Enrique LeandroIcon ; Kaufman, Teodoro SaulIcon
Fecha de publicación: 04/2014
Editorial: Royal Society of Chemistry
Revista: Organic & Biomolecular Chemistry
ISSN: 1477-0520
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

An efficient one-pot synthetic approach towards β-methylstyrenes is reported. The transformation, based on sequential homobimetallic catalysis, involves a Stille cross-coupling reaction between aryl halides and allyltributylstannane, followed by an in situ palladium-catalyzed conjugative isomerization. The reaction was optimized, and the best results were obtained with 10 mol% Pd(PPh3)2Cl2, 8.0 equiv. LiCl, and 0.5 equiv. PPh3 in diglyme at 130 °C for 12 h. It was demonstrated that the reaction tolerates a wide variety of functional groups
Palabras clave: Homobimetallic Catalysis , Palladium , Isomerisation , Beta-Methylstyrenes
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
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URI: http://hdl.handle.net/11336/29752
DOI: http://dx.doi.org/10.1039/c4ob00604f
URL: http://pubs.rsc.org/en/Content/ArticleLanding/2014/OB/C4OB00604F
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Citación
Simonetti, Sebastián Osvaldo; Larghi, Enrique Leandro; Kaufman, Teodoro Saul; A facile and convenient sequential homobimetallic catalytic approach towards β-methylstyrenes. A one-pot Stille cross-coupling/isomerization strategy; Royal Society of Chemistry; Organic & Biomolecular Chemistry; 12; 4-2014; 3735-3743
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