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dc.contributor.author
Villena, Julio Cesar
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dc.contributor.author
Kitazawa, Haruki
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dc.date.available
2015-11-24T16:16:53Z
dc.date.issued
2014-01-14
dc.identifier.citation
Villena, Julio Cesar; Kitazawa, Haruki; Modulation of intestinal TLR4-inflammatory signalling pathways by probiotic microorganisms: lessons learned from Lactobacillus jensenii TL2937; Frontiers Res Found; Frontiers in immunology; 4; 14-1-2014; 1-12
dc.identifier.issn
1664-3224
dc.identifier.uri
http://hdl.handle.net/11336/2901
dc.description.abstract
The intestinal mucosa plays a critical role in the host?s interactions with innocuous commen- sal microbiota and invading pathogenic microorganisms. Intestinal epithelial cells (IECs) and gut associated immune cells recognize the bacterial components via pattern-recognition receptors (PRRs) and are responsible for maintaining tolerance to the large communities of resident luminal bacteria while being also able to mount inflammatory responses against pathogens. Toll-like receptors (TLRs) are a major class of PRRs that are present on IECs and immune cells which are involved in the induction of both tolerance and inflammation. A growing body of experimental and clinical evidence supports the therapeutic and preven- tive application of probiotics for several gastrointestinal inflammatory disorders in which TLRs exert a significant role. This review aims to summarize the current knowledge of the beneficial effects of probiotic microorganisms with the capacity to modulate the immune system (immunobiotics) in the regulation of intestinal inflammation in pigs, which are very important as both livestock and human model. Especially we discuss the role of TLRs, their signaling pathways, and their negative regulators in both the inflammatory intestinal injury and the beneficial effects of immunobiotics in general, and Lactobacillus jensenii TL2937 in particular.This review article emphasizes the cellular and molecular interactions of immuno- biotics with IECs and immune cells through TLRs and their application for improving animal and human health.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Frontiers Res Found
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
LACTOBACILLUS JENSENII TL2937
dc.subject
INTESTINAL IMMUNITY AND INFLAMMATION
dc.subject
TLR4
dc.subject
IMMUNOBIOTICS
dc.subject.classification
Inmunología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Modulation of intestinal TLR4-inflammatory signalling pathways by probiotic microorganisms: lessons learned from Lactobacillus jensenii TL2937
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.journal.volume
4
dc.journal.pagination
1-12
dc.journal.pais
Che
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dc.journal.ciudad
Lausanne
dc.description.fil
Fil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia para Lactobacilos (i); Argentina
dc.description.fil
Fil: Kitazawa, Haruki. Tohoku University; Japón
dc.journal.title
Frontiers in immunology
dc.relation.isreferencedin
info:eu-repo/semantics/reference/url/info:eu-repo/semantics/reference es info:eu-repo/semantics/reference/pmid/http://www.ncbi.nlm.nih.gov/pmc/journals/1754/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/http://www.ncbi.nlm.nih.gov/pmc/journals/1754/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fimmu.2013.00512
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.frontiersin.org/immunology
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