Artículo

Steroid protection in the experimental autoimmune encephalomyelitis model of multiple sclerosis

Garay, Laura InesIcon ; Gonzalez Deniselle, Maria ClaudiaIcon ; Gierman, Lobke; Meyer, MariaIcon ; Lima, Analia EthelIcon ; Roig, PaulinaIcon ; de Nicola, Alejandro FedericoIcon
Fecha de publicación: 07/2008
Editorial: Karger
Revista: Neuroimmunomodulation
ISSN: 1021-7401
e-ISSN: 1423-0216
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

Based on evidence that pregnant women with multiple sclerosis (MS) show a decline in the relapse rate during the third trimester and an increase during the first 3 months postpartum, the suggestion was made that high levels of circulating sex steroids are responsible for pregnancy-mediated neuroprotection. As both estradiol (E(2)) and progesterone exert neuroprotective and myelinating effects on the nervous system, the effects of sex steroids were studied in the experimental autoimmune encephalomyelitis (EAE) model of MS.
Palabras clave: Experimental Autoimmune Encephalomyelitis , Multiple Sclerosis , Estradiol , Progesterone , Myelination , Neuroprotection
 
Archivos asociados
Thumbnail
 
Tamaño: 201.9Kb
Formato: PDF
.
Licencia
info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/26145
URL: https://www.karger.com/Article/Abstract/135627
DOI: http://dx.doi.org/10.1159/000135627
Colecciones
Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Garay, Laura Ines; Gonzalez Deniselle, Maria Claudia; Gierman, Lobke; Meyer, Maria; Lima, Analia Ethel; et al.; Steroid protection in the experimental autoimmune encephalomyelitis model of multiple sclerosis; Karger; Neuroimmunomodulation; 15; 1; 7-2008; 76-83
Compartir
Altmétricas