Artículo
Modulation of Nitro-fatty acid signaling: prostaglandin reductase-1 is a Nitroalkene reductase
Vitturi, Dario A.; Chen, Chen Shan; Woodcock, Steven R.; Salvatore, Sonia R.; Bonacci, Gustavo Roberto
; Koenitzer, Jeffrey R.; Stewart, Nicolas A.; Wakabayashi, Nobunao; Kensler, Thomas W.; Freeman, Bruce A.; Schopfer, Francisco J.
; Koenitzer, Jeffrey R.; Stewart, Nicolas A.; Wakabayashi, Nobunao; Kensler, Thomas W.; Freeman, Bruce A.; Schopfer, Francisco J.
Fecha de publicación:
08/2013
Editorial:
American Society for Biochemistry and Molecular Biology
Revista:
Journal of Biological Chemistry (online)
ISSN:
0021-9258
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Background: Nitroalkenes are electrophilic anti-inflammatory mediators that signal via Michael addition and are metabolized in vivo. Results: Prostaglandin reductase-1 is identified as a nitroalkene reductase. Conclusion: Prostaglandin reductase-1 reduces fatty acid nitroalkenes to nitroalkanes, inactivating electrophilic reactivity. Significance: A mammalian enzyme is identified that metabolizes fatty acid nitroalkenes in vivo to silence their signaling reactions.
Palabras clave:
Eicosanoid-Specific Enzymes
,
Electrophile
,
Nitro-Fatty Acid
,
Redox Signaling
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2.399Mb
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Licencia
Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción:
Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
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Colecciones
Articulos(CIBICI)
Articulos de CENTRO DE INV.EN BIOQUI.CLINICA E INMUNOLOGIA
Articulos de CENTRO DE INV.EN BIOQUI.CLINICA E INMUNOLOGIA
Citación
Vitturi, Dario A.; Chen, Chen Shan; Woodcock, Steven R.; Salvatore, Sonia R.; Bonacci, Gustavo Roberto; et al.; Modulation of Nitro-fatty acid signaling: prostaglandin reductase-1 is a Nitroalkene reductase; American Society for Biochemistry and Molecular Biology; Journal of Biological Chemistry (online); 288; 35; 8-2013; 25626-25637
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