Mostrar el registro sencillo del ítem
dc.contributor.author
Giudice, Jimena
dc.contributor.author
Jares, Elizabeth Andrea
dc.contributor.author
Coluccio Leskow, Federico
dc.date.available
2015-10-16T19:58:51Z
dc.date.issued
2013-06
dc.identifier.citation
Giudice, Jimena; Jares, Elizabeth Andrea; Coluccio Leskow, Federico; Insulin receptor membrane retention by a traceable chimeric mutant; Biomed Central; Cell Communication and Signaling; 11; 45; 6-2013; 1-13
dc.identifier.issn
1478-811X
dc.identifier.uri
http://hdl.handle.net/11336/2541
dc.description.abstract
Background: The insulin receptor (IR) regulates glucose homeostasis, cell growth and differentiation. It has been hypothesized that the specific signaling characteristics of IR are in part determined by ligand-receptor complexes localization. Downstream signaling could be triggered from the plasma membrane or from endosomes. Regulation of activated receptor's internalization has been proposed as the mechanism responsible for the differential isoform and ligand-specific signaling.
Results: We generated a traceable IR chimera that allows the labeling of the receptor at the cell surface. This mutant binds insulin but fails to get activated and internalized. However, the mutant heterodimerizes with wild type IR inhibiting its auto-phosphorylation and blocking its internalization. IR membrane retention attenuates AP-1 transcriptional activation favoring Akt activation.
Conclusions: These results suggest that the mutant acts as a selective dominant negative blocking IR internalization-mediated signaling.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Biomed Central
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
Insulin
dc.subject
Insulin Receptor
dc.subject
Endocytosis
dc.subject
Membrane Retention
dc.subject.classification
Bioquímica y Biología Molecular
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Insulin receptor membrane retention by a traceable chimeric mutant
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.journal.volume
11
dc.journal.number
45
dc.journal.pagination
1-13
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Giudice, Jimena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica; Argentina
dc.description.fil
Fil: Jares, Elizabeth Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono; Argentina
dc.description.fil
Fil: Coluccio Leskow, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica; Argentina. Universidad Nacional de Luján. Departamento de Ciencias Básicas; Argentina
dc.journal.title
Cell Communication and Signaling
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/doi:10.1186/1478-811X-11-45
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707766/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1186%2F1478-811X-11-45
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.biosignaling.com/content/11/1/45
Archivos asociados