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dc.contributor.author
Vera Candioti, Luciana
dc.contributor.author
Culzoni, Maria Julia
dc.contributor.author
Olivieri, Alejandro Cesar
dc.contributor.author
Goicoechea, Hector Casimiro
dc.date.available
2017-09-28T20:40:39Z
dc.date.issued
2008-12
dc.identifier.citation
Vera Candioti, Luciana; Culzoni, Maria Julia; Olivieri, Alejandro Cesar; Goicoechea, Hector Casimiro; Chemometric resolution of fully overlapped capillary electrophoresis peaks: quantitation of carbamazepine in human serum in the presence of several interferences; Wiley VCH Verlag; Electrophoresis; 29; 22; 12-2008; 4527-4537
dc.identifier.issn
0173-0835
dc.identifier.uri
http://hdl.handle.net/11336/25385
dc.description.abstract
Drug monitoring in serum samples was performed using second-order data generated by CE-DAD, processed with a suitable chemometric strategy. Carbamazepine could be accurately quantitated in the presence of its main metabolite (carbamazepine epoxide),other therapeutic drugs (lamotrigine, phenobarbital, phenytoin, phenylephrine,ibuprofen, acetaminophen, theophylline, caffeine, acetyl salicylic acid), and additional<br />serum endogenous components. The analytical strategy consisted of the following steps:(i) serum sample clean-up to remove matrix interferences, (ii) data pre-processing,in order to reduce the background and to correct for electrophoretic time shifts, and (iii) resolution of fully overlapped CE peaks (corresponding to carbamazepine, its metabolite, lamotrigine and unexpected serum components) by the well-known multivariate curve resolution-alternating least squares algorithm, which extracts quantitative information that can be uniquely ascribed to the analyte of interest. The analyte concentration in serum samples ranged from 2.00 to 8.00 mg/L. Mean recoveries<br />were 102.6% (s57.7) for binary samples, and 94.8% (s513.5) for spiked serum samples,while CV (%)54.0 was computed for five replicate, indicative of the acceptable accuracy and precision of the proposed method
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley VCH Verlag
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Carbamazepine
dc.subject
Overlapped Peaks
dc.subject
Second-Order Advantage
dc.subject.classification
Otras Ciencias Químicas
dc.subject.classification
Ciencias Químicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Chemometric resolution of fully overlapped capillary electrophoresis peaks: quantitation of carbamazepine in human serum in the presence of several interferences
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-09-25T18:21:20Z
dc.journal.volume
29
dc.journal.number
22
dc.journal.pagination
4527-4537
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Vera Candioti, Luciana. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Química. Cátedra de Química Analítica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Culzoni, Maria Julia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Química. Cátedra de Química Analítica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Olivieri, Alejandro Cesar. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Analítica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Goicoechea, Hector Casimiro. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Química. Cátedra de Química Analítica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Electrophoresis
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/elps.200800400
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/elps.200800400/abstract
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