Artículo
Effects of irradiated biodegradable polymer in endothelial cell monolayer formation
Arbeitman, Claudia Roxana
; del Grosso, Mariela Fernanda
; Behar, Moni; Garcia Bermudez, Gerardo Jose
Fecha de publicación:
06/2013
Editorial:
Elsevier
Revista:
Nuclear Instruments and Methods in Physics Research B: Beam Interactions with Materials and Atoms
ISSN:
0168-583X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
In this work we study cell adhesion, proliferation and cell morphology of endothelial cell cultured on poly-l-lactide acid (PLLA) modified by heavy ion irradiation. Thin films of PLLA samples were irradiated with sulfur (S) at energies of 75 MeV and gold (Au) at 18 MeV ion-beams. Ion beams were provided by the Tandar (Buenos Aires, Argentina) and Tandetron (Porto Alegre, Brazil) accelerators, respectively. The growth of a monolayer of bovine aortic endothelial cells (BAEC) onto unirradiated and irradiated surfaces has been studied by in vitro techniques in static culture. Cell viability and proliferation increased on modified substrates. But the results on unirradiated samples, indicate cell death (necrosis/apoptosis) with the consequent decrease in proliferation. We analyzed the correlation between irradiation parameters and cell metabolism and morphology.
Palabras clave:
Plla
,
Irradiated Polymers
,
Swift Heavy Ions
,
Cell Proliferation
,
Cell Adhesion
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Identificadores
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Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Arbeitman, Claudia Roxana; del Grosso, Mariela Fernanda; Behar, Moni; Garcia Bermudez, Gerardo Jose; Effects of irradiated biodegradable polymer in endothelial cell monolayer formation; Elsevier; Nuclear Instruments and Methods in Physics Research B: Beam Interactions with Materials and Atoms; 314; 6-2013; 86-89
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