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Artículo

Organization of brain networks governed by long-range connections index autistic traits in the general population

Barttfeld, PabloIcon ; Amoruso, LucíaIcon ; Ais, Joaquin; Cukier, Sebastián; Bavassi, Mariana LuzIcon ; Tomio, Ailin; Manes, Facundo FranciscoIcon ; Ibañez, Agustin MarianoIcon ; Sigman, MarianoIcon
Fecha de publicación: 06/2013
Editorial: BioMed Central
Revista: Journal of Neurodevelopmental Disorders
ISSN: 1866-1947
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Neurociencias; Neurología Clínica

Resumen

Background: The dimensional approach to Autism Spectrum Disorder (ASD) considers ASD as the extreme of a dimension traversing through the entire population. We use electroencephalography (EEG) functional connectivity to explore its potential utility as a biomarker. We hypothesized that individual differences in autistic traits of typical subjects would involve a long-range connectivity diminution within the delta band. Methods: Resting state EEG functional connectivity was measured for 74 neurotypical subjects. All participants also provided a questionnaire (Social Responsiveness Score, SRS) by an informant who knows the participant in social settings. We conducted multivariate regression between SRS score and functional connectivity in all EEG frequency bands. We explored modulations of network graph metrics characterizing the optimality of a network by SRS score. Results: Our results show a decay in functional connectivity mainly within delta and theta band (the lower part of the EEG spectrum) associated with increasing amount of autistic traits. When inspecting the impact of autistic traits on the global organization of functional network we found that optimal properties of the network are inversely related to the amount of autistic traits, suggesting that the autistic dimension, throughout the entire population, modulates the efficiency of functional brain networks. Conclusions: EEG functional connectivity at low frequencies and its associated network properties may be associated with some autistic traits in the general population.
Palabras clave: Autism Spectrum Disorders , Electroencephalography , Autistic Traits , Synchronization Likelihood , Small World , Long-Range Connections
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution 2.5 Unported (CC BY 2.5)
Identificadores
URI: http://hdl.handle.net/11336/2471
URL: http://www.jneurodevdisorders.com/content/5/1/16
URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698083/
DOI: http://dx.doi.org/10.1186%2F1866-1955-5-16
Colecciones
Articulos(IFIBA)
Articulos de INST.DE FISICA DE BUENOS AIRES
Articulos(IRICE)
Articulos de INST.ROSARIO DE INVEST.EN CS.DE LA EDUC. (I)
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Citación
Barttfeld, Pablo; Amoruso, Lucía; Ais, Joaquin; Cukier, Sebastián; Bavassi, Mariana Luz; et al.; Organization of brain networks governed by long-range connections index autistic traits in the general population; BioMed Central; Journal of Neurodevelopmental Disorders; 5; 16; 6-2013; 1-9
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