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dc.contributor.author Kruse, Maria Sol
dc.contributor.author Prémont, Joel
dc.contributor.author Krebs, Marie Odile
dc.contributor.author Jay, Therese M.
dc.date.available 2017-09-18T15:42:22Z
dc.date.issued 2009-01
dc.identifier.citation Kruse, Maria Sol; Prémont, Joel; Krebs, Marie Odile; Jay, Therese M.; Interaction of dopamine D1 with NMDA NR1 receptors in rat prefrontal cortex; Elsevier; European Neuropsychofarmacology; 19; 4; 1-2009; 296-304
dc.identifier.issn 0924-977X
dc.identifier.uri http://hdl.handle.net/11336/24458
dc.description.abstract Despite the tremendous importance of D1 and NMDA receptors to cognition (working memory, executive functions) and synaptic plasticity in the prefrontal cortex (PFC), little is known about the molecular mechanisms underlying D1-NMDA receptors interactions in this brain area. Here, we show that D1 receptors and the NMDA receptor co-localize in single pyramidal neurons and interneurons in adult rat PFC. NR1 and NR2A expression are found in different neuronal types. Conversely, D1 receptors are predominantly localized in pyramidal-like cells and parvalbumin positive cells. NR1 co-immunoprecipitates with D1 receptor in adult medial PFC. In prefrontal primary cultures, NMDA does not affect the D1 receptor dependent-cAMP production. In contrast, activation of D1 receptor potentiates the NMDA mediated increase in cytosolic Ca2+, an effect that was blocked by a PKA inhibitor. We conclude that D1 receptor potentiates the NMDA-Ca2+ signal by a PKA-dependent mechanism.
dc.format application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject DOPAMINE D1 RECEPTOR
dc.subject NMDA
dc.subject PREFRONTAL CORTEX
dc.subject CALCIUM
dc.subject.classification Neurociencias
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Interaction of dopamine D1 with NMDA NR1 receptors in rat prefrontal cortex
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-09-13T20:40:11Z
dc.identifier.eissn 1873-7862
dc.journal.volume 19
dc.journal.number 4
dc.journal.pagination 296-304
dc.journal.pais Países Bajos
dc.journal.ciudad Amsterdam
dc.description.fil Fil: Kruse, Maria Sol. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Inserm; Francia. Universite de Paris V; Francia
dc.description.fil Fil: Prémont, Joel. Inserm; Francia. Universite de Paris V; Francia
dc.description.fil Fil: Krebs, Marie Odile. Inserm; Francia. Universite de Paris V; Francia
dc.description.fil Fil: Jay, Therese M.. Inserm; Francia. Universite de Paris V; Francia
dc.journal.title European Neuropsychofarmacology
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://www.europeanneuropsychopharmacology.com/article/S0924-977X(08)00313-1/abstract
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.euroneuro.2008.12.006
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0924977X08003131


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)