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dc.contributor.author
Kruse, Maria Sol
dc.contributor.author
Prémont, Joel
dc.contributor.author
Krebs, Marie Odile
dc.contributor.author
Jay, Therese M.
dc.date.available
2017-09-18T15:42:22Z
dc.date.issued
2009-01
dc.identifier.citation
Kruse, Maria Sol; Prémont, Joel; Krebs, Marie Odile; Jay, Therese M.; Interaction of dopamine D1 with NMDA NR1 receptors in rat prefrontal cortex; Elsevier; European Neuropsychofarmacology; 19; 4; 1-2009; 296-304
dc.identifier.issn
0924-977X
dc.identifier.uri
http://hdl.handle.net/11336/24458
dc.description.abstract
Despite the tremendous importance of D1 and NMDA receptors to cognition (working memory, executive functions) and synaptic plasticity in the prefrontal cortex (PFC), little is known about the molecular mechanisms underlying D1-NMDA receptors interactions in this brain area. Here, we show that D1 receptors and the NMDA receptor co-localize in single pyramidal neurons and interneurons in adult rat PFC. NR1 and NR2A expression are found in different neuronal types. Conversely, D1 receptors are predominantly localized in pyramidal-like cells and parvalbumin positive cells. NR1 co-immunoprecipitates with D1 receptor in adult medial PFC. In prefrontal primary cultures, NMDA does not affect the D1 receptor dependent-cAMP production. In contrast, activation of D1 receptor potentiates the NMDA mediated increase in cytosolic Ca2+, an effect that was blocked by a PKA inhibitor. We conclude that D1 receptor potentiates the NMDA-Ca2+ signal by a PKA-dependent mechanism.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Dopamine D1 Receptor
dc.subject
Nmda
dc.subject
Prefrontal Cortex
dc.subject
Calcium
dc.subject.classification
Neurociencias
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Interaction of dopamine D1 with NMDA NR1 receptors in rat prefrontal cortex
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-09-13T20:40:11Z
dc.identifier.eissn
1873-7862
dc.journal.volume
19
dc.journal.number
4
dc.journal.pagination
296-304
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Kruse, Maria Sol. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Inserm; Francia. Universite de Paris V; Francia
dc.description.fil
Fil: Prémont, Joel. Inserm; Francia. Universite de Paris V; Francia
dc.description.fil
Fil: Krebs, Marie Odile. Inserm; Francia. Universite de Paris V; Francia
dc.description.fil
Fil: Jay, Therese M.. Inserm; Francia. Universite de Paris V; Francia
dc.journal.title
European Neuropsychofarmacology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.europeanneuropsychopharmacology.com/article/S0924-977X(08)00313-1/abstract
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.euroneuro.2008.12.006
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0924977X08003131


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