PI3K pathway is involved in ERK signaling cascade activation by histamine H2R agonist in HEK293T cells

Histamine, through histamine H2 receptor (H2R), modulates different biological processes, involving the modulation of PI3K/AKT/mTOR and RAS/RAF/MEK/ERK pathways. Many evidences have demonstrated the existence and importance of the crossregulation between these two signaling pathways. The aim of the present work was to determine the molecular mechanisms leading to PI3K and ERK pathways modulation induced by the H2R agonist amthamine and to evaluate the possible interplay between them.

Palabras clave: Hiistamine H2 Receptor , Erk , Cell Proliferation , Cell Signalling

Ver el registro completo

Archivos asociados

Tamaño: 1.854Mb

Formato: PDF

Descargar

Licencia

Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

Identificadores

URI: http://hdl.handle.net/11336/24178

URL: http://www.sciencedirect.com/science/article/pii/S0304416516302215

DOI: http://dx.doi.org/10.1016/j.bbagen.2016.06.016

Colecciones

Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)

Articulos(ININFA)
Articulos de INST.DE INVEST.FARMACOLOGICAS (I)

Citación

Alonso, Maria Natalia; Díaz, Antonela Susana; Monczor, Federico; Gutkind, J. Silvio; Davio, Carlos Alberto; et al.; PI3K pathway is involved in ERK signaling cascade activation by histamine H2R agonist in HEK293T cells; Elsevier Science; Biochimica et Biophysica Acta- General Subjects; 1860; 9; 15-6-2016; 1998-2007

Altmétricas