Boron biodistribution for BNCT in the hamster cheek pouch oral cancer model: Combined administration of BSH and BPA

Sodium mercaptoundecahydro-closo-dodecaborate (BSH) is being investigated clinically for BNCT. We examined the biodistribution of BSH and BPA administered jointly in different proportions in the hamster cheek pouch oral cancer model. The 3 assayed protocols were non-toxic, and showed preferential tumor boron uptake versus precancerous and normal tissue and therapeutic tumor boron concentration values (70-85ppm). All 3 protocols warrant assessment in BNCT studies to contribute to the knowledge of (BSH+BPA)-BNCT radiobiology for head and neck cancer and optimize therapeutic efficacy.

Palabras clave: Boron Neutron Capture Therapy , Bnct , Oral Cancer , Bpa , Bsh , Hamster Cheek Pouch Oral Cancer Model

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

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URI: http://hdl.handle.net/11336/24103

DOI: http://dx.doi.org/10.1016/j.apradiso.2013.11.118

URL: http://www.sciencedirect.com/science/article/pii/S0969804313005678

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Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL

Citación

Garabalino, Marcela Alejandra; Heber, Elisa Mercedes; Monti Hughes, Andrea; Pozzi, Emiliano César Cayetano; Molinari, Ana Julia; et al.; Boron biodistribution for BNCT in the hamster cheek pouch oral cancer model: Combined administration of BSH and BPA; Elsevier; Applied Radiation and Isotopes; 88; 12-2013; 64-68

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