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dc.contributor.author Daneri Becerra, Cristina del Rosario
dc.contributor.author Galigniana, Mario Daniel
dc.date.available 2017-09-07T19:49:23Z
dc.date.issued 2016-08-22
dc.identifier.citation Daneri Becerra, Cristina del Rosario; Galigniana, Mario Daniel; Regulatory role of heat-shock proteins in autoimmune and inflammatory diseases; Open Access Text; Integrative Molecular Medicine; 4; 22-8-2016
dc.identifier.uri http://hdl.handle.net/11336/23798
dc.description.abstract Classically, molecular chaperones play a pivotal role in the maintenance of cellular proteostasis and thus, in the safeguarding of the cell homeostasis while reducing the deleterious effects of extracellular and intracellular stresses. They are also active players in immunologically relevant scenarios such as the activation of innate immunity, antitumour immunity, and autoimmune diseases. It is currently accepted that misdirected immune responses may target self-antigens and generate severe inflammatory responses, a typical signature of autoimmune diseases. In addition to numerous components in immune responses, chaperone proteins are also detected in the extracellular fluids and have been implicated in autoimmune and inflammatory diseases acting as pro- and anti-inflammatory factors. In several inflammatory pathologies, chaperones are greatly induced as a direct consequence of the inflammatory stress and are released from the cell thanks to a poorly understood mechanism. These extracellular chaperones are capable to stimulate anti-inflammatory regulatory T cell responses, thereby inducing the negative feedback control of inflammation. Therefore, it has been proposed that immunization with heat-shock protein peptides could prevent the development of certain diseases. In this article we review the basics of the stress response, summarize current controversies over the role of extracellular chaperones in inflammatory reactions and autoimmunity, and discuss the cytoprotective and immunoregulatory roles of heat-shock proteins, a challenging subject that may open a new avenue for the drug discovery and treatment of diseases related to autoimmune disturbs.
dc.format application/pdf
dc.language.iso eng
dc.publisher Open Access Text
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject HSP90
dc.subject HSF1
dc.subject AUTOIMMUNITY
dc.subject Hsp70
dc.subject.classification Bioquímica y Biología Molecular
dc.subject.classification Ciencias Biológicas
dc.subject.classification CIENCIAS NATURALES Y EXACTAS
dc.title Regulatory role of heat-shock proteins in autoimmune and inflammatory diseases
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-08-31T20:29:38Z
dc.identifier.eissn 2056-6360
dc.journal.volume 4
dc.journal.pais Reino Unido
dc.journal.ciudad Londres
dc.description.fil Fil: Daneri Becerra, Cristina del Rosario. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil Fil: Galigniana, Mario Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.journal.title Integrative Molecular Medicine
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://www.oatext.com/Regulatory-role-of-heat-shock-proteins-in-autoimmune-and-inflammatory-diseases.php#Article


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    Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)

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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)