Artículo
The gut-lung axis and asthma susceptibility in early life
Fecha de publicación:
01/2024
Editorial:
John Wiley & Sons Ltd
Revista:
Acta Physiologica
e-ISSN:
1748-1716
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Asthma is the most common chronic disease among children, with more than 300million cases worldwide. Over the past several decades, asthma incidence has grown, and epidemiological studies identify the modernized lifestyle as playing a strong contributing role in this phenomenon. In particular, lifestyle factors that modify the maternal gut microbiome during pregnancy, or the infant microbiome in early life, can act as developmental programming events which determine health or disease susceptibility later in life. Microbial colonization of the gut begins at birth, and factors such as delivery mode, breastfeeding, diet, antibiotic use, and exposure to environmental bacteria influence the development of the infant microbiome. Colonization of the gut microbiome is crucial for proper immune system development and disruptions to this process can predispose a child to asthma development. Here, we describe the importance of early-life events for shaping immune responses along the gut-lung axis and why they may provide a window of opportunity for asthma prevention.
Palabras clave:
ANTIBIOTIC
,
ASTHMA
,
DOHAD
,
EARLY LIFE
,
GUT-LUNG AXIS
,
HYGIENE HYPOTHESIS
,
MICROBIOME
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Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Kahhaleh, Fariz G.; Barrientos, Gabriela Laura; Conrad, Melanie L.; The gut-lung axis and asthma susceptibility in early life; John Wiley & Sons Ltd; Acta Physiologica; 240; 3; 1-2024; 1-15
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