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dc.contributor.author
Barros, Ana Luisa A. N.
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Silva, Vladimir C.
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Ribeiro Junior, Atvaldo F.
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Cardozo, Miguel G.
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Costa, Samuel R.
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Moraes, Carolina B.
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Barbosa, Cecilia G.
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Coleone, Alex P.
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Simões, Rafael P.
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Cabral, Wanessa F.
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Falcão, Raul M.
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Vasconcelos, Andreanne G.
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Rocha, Jefferson A.
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Arcanjo, Daniel D. R.
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Batagin Neto, Augusto
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Borges, Tatiana K. S.
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Gonçalves, João
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Brand, Guilherme D.
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Freitas Junior, Lucio H.G.
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Eaton, Peter
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Marani, Mariela Mirta
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Kato, Massuo J.
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Plácido, Alexandra
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Leite, José Roberto S. A.
dc.date.available
2024-04-22T10:27:16Z
dc.date.issued
2024-01
dc.identifier.citation
Barros, Ana Luisa A. N.; Silva, Vladimir C.; Ribeiro Junior, Atvaldo F.; Cardozo, Miguel G.; Costa, Samuel R.; et al.; Antiviral action against SARS-CoV-2 of a synthetic peptide based on a Novel defensin present in the transcriptome of the fire salamander (Salamandra salamandra); Multidisciplinary Digital Publishing Institute; Pharmaceutics; 16; 2; 1-2024; 1-19
dc.identifier.issn
1999-4923
dc.identifier.uri
http://hdl.handle.net/11336/233645
dc.description.abstract
The potential emergence of zoonotic diseases has raised significant concerns, particularly in light of the recent pandemic, emphasizing the urgent need for scientific preparedness. The bioprospection and characterization of new molecules are strategically relevant to the research and development of innovative drugs for viral and bacterial treatment and disease management. Amphibian species possess a diverse array of compounds, including antimicrobial peptides. This study identified the first bioactive peptide from Salamandra salamandra in a transcriptome analysis. The synthetic peptide sequence, which belongs to the defensin family, was characterized through MALDI TOF/TOF mass spectrometry. Molecular docking assays hypothesized the interaction between the identified peptide and the active binding site of the spike WT RBD/hACE2 complex. Although additional studies are required, the preliminary evaluation of the antiviral potential of synthetic SS-I was conducted through an in vitro cell-based SARS-CoV-2 infection assay. Additionally, the cytotoxic and hemolytic effects of the synthesized peptide were assessed. These preliminary findings highlighted the potential of SS-I as a chemical scaffold for drug development against COVID-19, hindering viral infection. The peptide demonstrated hemolytic activity while not exhibiting cytotoxicity at the antiviral concentration.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Multidisciplinary Digital Publishing Institute
dc.rights
info:eu-repo/semantics/openAccess
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https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
AMPHIBIANS
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TRANSCRIPTOMICS
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ANTIMICROBIAL PEPTIDES
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BIOINFORMATICS
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ANTIVIRAL ACTION
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SARS-CoV-2 INFECTION
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Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
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dc.title
Antiviral action against SARS-CoV-2 of a synthetic peptide based on a Novel defensin present in the transcriptome of the fire salamander (Salamandra salamandra)
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-04-10T16:04:13Z
dc.journal.volume
16
dc.journal.number
2
dc.journal.pagination
1-19
dc.journal.pais
Suiza
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Fil: Barros, Ana Luisa A. N.. Universidade do Brasília; Brasil
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Fil: Silva, Vladimir C.. Universidade do Brasília; Brasil
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Fil: Ribeiro Junior, Atvaldo F.. Universidade do Brasília; Brasil
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Fil: Cardozo, Miguel G.. Universidade do Brasília; Brasil. Universidade Nova de Lisboa; Portugal
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Fil: Costa, Samuel R.. Universidade do Brasília; Brasil
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Fil: Moraes, Carolina B.. Universidade de Sao Paulo; Brasil
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Fil: Barbosa, Cecilia G.. Universidade de Sao Paulo; Brasil
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Fil: Coleone, Alex P.. Universidade de Sao Paulo; Brasil
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Fil: Simões, Rafael P.. Universidade de Sao Paulo; Brasil
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Fil: Cabral, Wanessa F.. Universidade do Brasília; Brasil
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Fil: Falcão, Raul M.. Universidade Federal do Rio Grande do Norte; Brasil
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Fil: Vasconcelos, Andreanne G.. Universidade do Brasília; Brasil
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Fil: Rocha, Jefferson A.. Universidade Federal Do Maranhao.; Brasil
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Fil: Arcanjo, Daniel D. R.. Universidade Federal Do Piaui.; Brasil
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Fil: Batagin Neto, Augusto. Universidade de Sao Paulo; Brasil
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Fil: Borges, Tatiana K. S.. Universidade do Brasília; Brasil
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Fil: Gonçalves, João. Universidade Nova de Lisboa; Portugal
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Fil: Brand, Guilherme D.. Universidade do Brasília; Brasil
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Fil: Freitas Junior, Lucio H.G.. Universidade de Sao Paulo; Brasil
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Fil: Eaton, Peter. Universidad de Porto; Portugal
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Fil: Marani, Mariela Mirta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico para el Estudio de los Ecosistemas Continentales; Argentina
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Fil: Kato, Massuo J.. Universidade de Sao Paulo; Brasil
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Fil: Plácido, Alexandra. Universidad de Porto; Portugal
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Fil: Leite, José Roberto S. A.. Universidade do Brasília; Brasil
dc.journal.title
Pharmaceutics
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/pharmaceutics16020190
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1999-4923/16/2/190
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