Mostrar el registro sencillo del ítem
dc.contributor.author
Colussi, Carlina Leila
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Martínez, Guillaume
dc.contributor.author
Bellenger, Jean-Philippe
dc.contributor.author
Poletta, Gisela Laura
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Simoniello, Maria Fernanda
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.date.available
2024-04-18T13:26:43Z
dc.date.issued
2024-01
dc.identifier.citation
Colussi, Carlina Leila; Martínez, Guillaume; Bellenger, Jean-Philippe; Poletta, Gisela Laura; Simoniello, Maria Fernanda; Prenatal exposure to pesticide mixture in Argentina: A pilot study in puerperal women from Santa Fe province; John Wiley & Sons; Birth Defects Research; 116; 2; 1-2024; 1-15
dc.identifier.uri
http://hdl.handle.net/11336/233455
dc.description.abstract
Introduction: The epidemiological investigation of congenital anomalies (CA) represents a challenge due to the multiplicity of associated risk factors, notably environmental ones. The monitoring of genotoxic effects in different populations is a useful tool in human biomonitoring and has great biological importance in estimating the exposure risks to complex mixtures of chemicalsubstances.Objective: This study aimed to determine the presence of environmental xenobiotics and evaluate their genotoxic effect, in mothers of newborns with and without CA, and the possible association/correlation between those biomarkers and CA.Materials and methods: A descriptive case and control cross-sectional study was developed on 290 postpartum women from Santa Fe, Argentina.Results: Significant differences were observed between both groups, for places of residence and gynecological variables. Metabolites of organochlorine (OC), organophosphate (OP), and pyrethroid (PYR) pesticides were detected. The most frequently detected compounds were atrazine (ATZ) (57.14%), carbendazim (CBZ) (46.42%), and methylparaben (46.42%), among others. A positivecorrelation was found between the number of pesticides in blood and genotoxic variables. On the other hand, mothers of children with genitourinary anomalies were the ones with the highest concentrations of ATZ and OP. Discussion and conclusion: These results showed a deep background in the health reality of Santa Fe, which could greatly impact the health of future adults, who have been born preterm. On the other hand, the mixture of pesticides detected confirms the environmental living conditions of women and the transplacental exposure to these compounds in each pregnancy. The potential effects on long-term descendent health are unknown and unpredictable.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
John Wiley & Sons
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Argentina
dc.subject
Biological monitoring
dc.subject
Biomarkers
dc.subject
DNA damage
dc.subject
Maternal–fetal exchange
dc.subject
Pesticides
dc.subject
Pregnancy
dc.subject.classification
Salud Pública y Medioambiental
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
Ciencias de la Salud
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.title
Prenatal exposure to pesticide mixture in Argentina: A pilot study in puerperal women from Santa Fe province
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-04-10T12:02:30Z
dc.identifier.eissn
2472-1727
dc.journal.volume
116
dc.journal.number
2
dc.journal.pagination
1-15
dc.journal.pais
Estados Unidos
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.description.fil
Fil: Colussi, Carlina Leila. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Cátedra de Toxicología y Bioquímica Legal; Argentina
dc.description.fil
Fil: Martínez, Guillaume. University of Sherbrooke; Canadá
dc.description.fil
Fil: Bellenger, Jean-Philippe. University of Sherbrooke; Canadá
dc.description.fil
Fil: Poletta, Gisela Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Cátedra de Toxicología y Bioquímica Legal; Argentina
dc.description.fil
Fil: Simoniello, Maria Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Cátedra de Toxicología y Bioquímica Legal; Argentina
dc.journal.title
Birth Defects Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/bdr2.2307
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/bdr2.2307
Archivos asociados