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dc.contributor.author
Furland, Natalia Edith
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dc.contributor.author
Sindelar, Maria Teresa
dc.date.available
2024-04-18T10:52:14Z
dc.date.issued
2015
dc.identifier.citation
Austism Spectrum Disorder and the Brain-Gut-Microbiome Axis; 2015 International Meeting for Autism Research; Salt Lake City; Estados Unidos; 2015; 731-731
dc.identifier.uri
http://hdl.handle.net/11336/233379
dc.description.abstract
Background: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder where a high frequency of gastrointestinal (GI) dysfunction (e.g., constipation, diarrhea, bloating, gas, and history of reflux) is reported. However, the mechanism underlying GI tract defects in autistic children as well as the association between abnormal GI structure and function with ASD is yet to be clearly understood. GABA and serotonin functions as key neurotransmitters at both, the central nervous system and the gastrointestinal tract, and there is accumulating evidence pointing to a critical role for the gut microbiome in regulating normal functioning of tryptophan metabolism and the GABAergic system. There is also substantial overlap between ASD behaviours that could be influenced by the gut microbiota. Objectives: the aim of this work is to analyse and identify differences on fecal microbiota (as a proxy for gut microbiota), some neurotransmitters levels and SCFA (short chain fatty acids) between autistic children and healthy donors. If the unique microbial flora or metabolic profile is found to be a causative or consequent factor in GI disorders in ASD, it may have implications with regard to a specific diagnostic test, its epidemiology, and therapeutic targeting of the gut microbiota as a viable treatment strategy for ASD Methods: we analyzed Serotonin and Dopamine, both neurotransmitter monoamines involved in modulating adult cortical plasticity, also GABA and SCFA (short chain fatty acids) profile in fecal samples in a cohort of 30 patients that met DSM V criteria for autism based on ADOS and their typical developed (TD) siblings. The control sample consisted of 35 healthy donors, sex-matched with the case sample. Results: Autistic patients have a unique microbiome consisting of more clostridial species. Half of all autistic children with gastrointestinal dysfunction were found to have Sutterella, a bacteria which is absent in no autistic children with gastrointestinal dysfunction. Our results show that microbiota and metabolic profiles from ADS children significantly differ from their healthy siblings and controls and suggest a potential correlation with gastrointestinal dysfunction. Conclusions: Differences in microbiota and some metabolites levels found in ADS children stools versus controls correlates with GI distress. Also CNS neurotransmission can be profoundly disturbed by the gut microbiome in ASD
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
International Meeting for Autism Research
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
AUTISM
dc.subject
IMMUNOLOGY
dc.subject
MICROBIOME
dc.subject
FATTY ACIDS
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Austism Spectrum Disorder and the Brain-Gut-Microbiome Axis
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/conferenceObject
dc.type
info:ar-repo/semantics/documento de conferencia
dc.date.updated
2024-01-16T14:34:50Z
dc.journal.pagination
731-731
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Connecticut
dc.description.fil
Fil: Furland, Natalia Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
dc.description.fil
Fil: Sindelar, Maria Teresa. Emily Fenichel Foundation; Argentina
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://insar.confex.com/insar/2015/webprogram/start.html
dc.conicet.rol
Autor
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dc.conicet.rol
Autor
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dc.coverage
Internacional
dc.type.subtype
Congreso
dc.description.nombreEvento
2015 International Meeting for Autism Research
dc.date.evento
2015-05-13
dc.description.ciudadEvento
Salt Lake City
dc.description.paisEvento
Estados Unidos
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dc.type.publicacion
Book
dc.description.institucionOrganizadora
International Society for Autism Research
dc.source.libro
International Meeting for Autism Research. Annual Meeting International Society for Autism Research (INSAR)
dc.source.revista
ABSTRACT BOOK IMFAR 2015
dc.date.eventoHasta
2015-05-16
dc.type
Congreso
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