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dc.contributor.author
Macchione, Ana Fabiola
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dc.date.available
2024-04-17T11:07:06Z
dc.date.issued
2023
dc.identifier.citation
Breathing alterations against hypoxia as a function of early ethanol exposure; XXXVIII Annual Meeting of the Sociedad Argentina de Investigación en Neurociencias; San Luis; Argentina; 2023; 60-60
dc.identifier.uri
http://hdl.handle.net/11336/233230
dc.description.abstract
Maternal ethanol (EtOH) intake during pregnancy and lactation is a highly frequent “social” behavior in Argentine, exposing fetus or neonates to moderate EtOH intoxication through the amniotic fluid and placenta. Early EtOH exposure triggers a spectrum of neurobehavioral dysfunctions affecting, also, the breathing response. In an animal model equivalent to the 3rd trimester of the human gestation we explore the early ethanol exposure effects on the ventilatory responses in normoxic and hypoxic-air conditions. We also study central areas involved in breathing modulation as the solitary tract nucleus and the medullary raphe system. Our results show that a brief and early ethanol exposure alters both basal and hypoxia-induced breathing frequencies and apneas through modifications in the activation patterns of central areas of study. Actually, early ethanol exposure induces a basal breathing depression in normoxic conditions but, against a hypoxic challenge, ethanol triggers two consecutive altered events: first a lower hyperventilation rate during the hypoxic event itself and then, during the post-hypoxic period, ethanol elicit the emergency of an adaptive phenomenon, the ventilatory long-term facilitation. Alterations in the activation patterns in the NTS and raphe obscurus, and an increase in the 5HT levels in the medullary raphe nuclei (magnus, obscurus y pallidus) were observed as a function of different ways of early ethanol exposure. Funding by MINCyT-Cba; FONCyT and SECyT-UNC.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Sociedad Argentina de Investigación en Neurociencias
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Ethanol
dc.subject
Hypoxia
dc.subject
Breeathing
dc.subject
Neonates
dc.subject.classification
Neurociencias
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Breathing alterations against hypoxia as a function of early ethanol exposure
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/conferenceObject
dc.type
info:ar-repo/semantics/documento de conferencia
dc.date.updated
2024-04-16T09:45:48Z
dc.journal.pagination
60-60
dc.journal.pais
Argentina
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dc.journal.ciudad
San Luis
dc.description.fil
Fil: Macchione, Ana Fabiola. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://csan2023.saneurociencias.org.ar/wp-content/uploads/2023/11/SANebook2023.pdf
dc.conicet.rol
Autor
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dc.coverage
Nacional
dc.type.subtype
Reunión
dc.description.nombreEvento
XXXVIII Annual Meeting of the Sociedad Argentina de Investigación en Neurociencias
dc.date.evento
2023-10-03
dc.description.ciudadEvento
San Luis
dc.description.paisEvento
Argentina
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dc.type.publicacion
Book
dc.description.institucionOrganizadora
Sociedad Argentina de Investigación en Neurociencias
dc.description.institucionOrganizadora
Universidad Nacional de San Luis
dc.source.libro
SAN2023: E-book
dc.date.eventoHasta
2023-10-07
dc.type
Reunión
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