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dc.contributor.author
Ivanovic, Jasna  
dc.contributor.author
Milovanovic, Stoja  
dc.contributor.author
Stamenic, Marko  
dc.contributor.author
Fanovich, Maria Alejandra  
dc.contributor.author
Jaeger, Philip  
dc.contributor.author
Zizovic, Irena  
dc.contributor.other
Osborne, Jane  
dc.date.available
2024-04-11T14:17:33Z  
dc.date.issued
2014  
dc.identifier.citation
Ivanovic, Jasna; Milovanovic, Stoja; Stamenic, Marko; Fanovich, Maria Alejandra; Jaeger, Philip; et al.; Application of an integrated supercritical extraction and impregnation process for incorporation of thyme extracts into different carriers; Nova Science Publishers; 1; 2014; 257-280  
dc.identifier.isbn
978-1-63321-930-4  
dc.identifier.uri
http://hdl.handle.net/11336/232725  
dc.description.abstract
Supercritical carbon dioxide (scCO2) is known as a good solvent for a wide range of bioactive compounds from natural sources. Extraction of bioactive compounds from plant material using scCO2 is a favorable technique for producing solvent-free extracts suitable for a wide range of applications in pharmaceutical, biomedical, cosmetic and food industries. Incorporation of drugs or other bioactive substances into polymeric matrices by conventional techniques is connected to some significant drawbacks (use of organic solvents, undesired substances reactions and/or degradation, low incorporation yields and heterogeneous dispersion). Supercritical solvent impregnation (SSI), and namely impregnation using scCO2, has been proposed as an alternative methodology to overcome most of these problems. The main advantages of this technique are avoidance of organic solvents and possibility to work at relatively low operational temperatures and with hydrophobic drugs/substances which cannot be impregnated by aqueous solution/suspension soaking methods. Additionally, unique physical and transport properties of scCO2 can be used simultaneously for impregnation of biopolymers and tailoring the chemistry and morphology thereof to obtain the desired microstructure of the final product. The present chapter is particularly aimed to demonstrate feasibility of incorporating of thyme extracts into different solid matrices by using a methodology that combines the supercritical fluid extraction (SFE) and SSI. Compared to both processes to be conducted separately, the advantage of using one single integrated process is basically to save energy and time by avoiding an intermediate decompression procedure. Representative commercial carriers with relevance for pharmaceutical, biomedical and food applications (cotton gauze, polypropylene non-woven fabrics, chitosan and starch gels, cellulose acetate and polycaprolactone) were used to test feasibility of thyme extract incorporation by the coupled SFE-SSI process. By setting the relevant parameters of each process separately, the challenge of this methodology aims to harmonize these parameters in order to increase the extraction and impregnation efficiencies as well as to obtain an even distribution of the solute within the solid matrix.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Nova Science Publishers  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Supercritical process  
dc.subject
Foaming  
dc.subject.classification
Ingeniería de Procesos Químicos  
dc.subject.classification
Ingeniería Química  
dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS  
dc.title
Application of an integrated supercritical extraction and impregnation process for incorporation of thyme extracts into different carriers  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.type
info:eu-repo/semantics/bookPart  
dc.type
info:ar-repo/semantics/parte de libro  
dc.date.updated
2021-12-03T19:50:08Z  
dc.journal.volume
1  
dc.journal.pagination
257-280  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Ivanovic, Jasna. University of Belgrade; Serbia  
dc.description.fil
Fil: Milovanovic, Stoja. University of Belgrade; Serbia  
dc.description.fil
Fil: Stamenic, Marko. University of Belgrade; Serbia  
dc.description.fil
Fil: Fanovich, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina  
dc.description.fil
Fil: Jaeger, Philip. Hamburg University of Technology; Alemania  
dc.description.fil
Fil: Zizovic, Irena. University of Belgrade; Serbia  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://novapublishers.com/shop/handbook-on-supercritical-fluids-fundamentals-properties-and-applications/  
dc.conicet.paginas
450  
dc.source.titulo
Handbook on supercritical fluids: Fundamentals, properties and applications