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dc.contributor.author
Casabona, Juan Cruz
dc.contributor.other
Buttermore, Elizabeth D.
dc.date.available
2024-04-09T10:18:48Z
dc.date.issued
2022
dc.identifier.citation
Casabona, Juan Cruz; Cell therapy and biomanufacturing using hiPSC-derived neurons; Elsevier; 2022; 313-338
dc.identifier.isbn
978-0128222775
dc.identifier.uri
http://hdl.handle.net/11336/232449
dc.description.abstract
Phenotyping of Human iPSC-derived Neurons: Patient-Driven Research examines the steps in a preclinical pipeline that utilizes iPSC-derived neuronal technology to better understand neurological disorders and identify novel therapeutics, also providing considerations and best practices. By presenting example projects that identify phenotypes and mechanisms relevant to autism spectrum disorder and epilepsy, this book allows readers to understand what considerations are important to assess at the start of project design. Sections address reproducibility issues and advances in technology at each stage of the pipeline and provide suggestions for improvement. From patient sample collection and proper controls to neuronal differentiation, phenotyping, screening, and considerations for moving to the clinic, these detailed descriptions of each stage of the pipeline will help everyone, regardless of stage in the pipeline. In recent years, drug discovery in the neurosciences has struggled to identify novel therapeutics for patients with varying indications, including epilepsy, chronic pain, and psychosis. Current treatment options for such patients are decades old and offer little relief with many side effects. One explanation for this lull in novel therapeutics is a lack of novel target identification for neurological disorders (and target identification requires exemplar preclinical data). To improve on the preclinical work that often relies on rodent modeling, the field has begun utilizing patient-derived induced pluripotent stem cells (iPSCs) to differentiate neurons in vitro for preclinical characterization of neurological disease and target identification.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Manufacturing
dc.subject
Reprogrammed Pluripotent Stem Cells
dc.subject
GMP
dc.subject.classification
Biotecnología relacionada con la Salud
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Biotecnología de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Cell therapy and biomanufacturing using hiPSC-derived neurons
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/bookPart
dc.type
info:ar-repo/semantics/parte de libro
dc.date.updated
2023-07-26T15:40:32Z
dc.journal.pagination
313-338
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Casabona, Juan Cruz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.elsevier.com/books/phenotyping-of-human-ipsc-derived-neurons/buttermore/978-0-12-822277-5
dc.conicet.paginas
372
dc.source.titulo
Phenotyping of Human iPSC-derived Neurons: Patient-Driven Research
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