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dc.contributor.author
Bardach, Ariel Esteban
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dc.contributor.author
Alconada, Tomás
dc.contributor.author
Palermo, Carolina
dc.contributor.author
Rojas Roque, Carlos
dc.contributor.author
Sandoval, María Macarena
dc.contributor.author
Gomez, Jorge
dc.contributor.author
Pinto, Thatiana
dc.contributor.author
Ciapponi, Agustín
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dc.date.available
2024-02-28T13:53:25Z
dc.date.issued
2023-06
dc.identifier.citation
Bardach, Ariel Esteban; Alconada, Tomás; Palermo, Carolina; Rojas Roque, Carlos; Sandoval, María Macarena; et al.; Burden of Disease of Gonorrhoea in Latin America: Systematic Review and Meta-analysis; Springer; Infectious Diseases and Therapy; 12; 6; 6-2023; 1505-1525
dc.identifier.issn
2193-8229
dc.identifier.uri
http://hdl.handle.net/11336/228813
dc.description.abstract
Introduction: Neisseria gonorrhoeae causes gonorrhoea, a globally neglected but increasing disease. This systematic review and meta-analysis reviewed the epidemiology and economic burden of gonorrhoea in Latin America and the Caribbean (LAC). Methods: We searched PubMed, EMBase, Cochrane Library, EconLIT, CINAHL, CRD, LILACS, Global Health, Global Dissertations and Theses, SciELO, Web of Science databases, countries’ ministries of health, and the IHME’s Global Burden of Disease databases. Studies published in the last 10 years (20 years for economic studies) were included if conducted in any LAC country, without language restrictions. The main outcome measures were incidence/prevalence, proportion of co-infections, case fatality rates, specific mortality/hospitalisation rates, direct/indirect costs, and impact of gonorrhoea on quality of life. To assess evidence quality, we used a checklist developed by the US National Heart, Lung, and Blood Institute for observational studies and trial control arms, the Cochrane Effective Practice Organization of Care Group tool for randomised controlled trials, and the CICERO checklist for economic studies. Results: We identified 1290 articles; 115 included epidemiological studies and one included an economic study. Ministry of health data from Argentina, Brazil, Chile, Colombia, Mexico, and Uruguay were identified. Gonorrhoea prevalence was 1.46% (95% confidence interval [CI] 1.00–2.00%) from 48 studies and 5.68% (95% CI 4.23–7.32%) from 58 studies for non-high-risk and high-risk populations, respectively. Cumulative incidence for the high-risk population was 2.05 cases per 100 persons/year. Few published studies were rated as “good” in the risk of bias assessments. Variations in the methodology of the sources and limited information found in the countries’ surveillance systems hinder the comparison of data. Conclusion: The burden of gonorrhoea in LAC is not negligible. Our results provide public health and clinical decision support to assess potential interventions to prevent gonorrhoea. Trial Registration: The protocol is registered on PROSPERO (CRD42021253342). The study was funded by GlaxoSmithKline Biologicals SA (GSK study identifier VEO-000025).
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.subject
CARIBBEAN
dc.subject
ECONOMICS
dc.subject
EPIDEMIOLOGY
dc.subject
GONORRHOEA
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LATIN AMERICA
dc.subject
SYSTEMATIC REVIEW
dc.subject.classification
Enfermedades Infecciosas
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dc.subject.classification
Ciencias de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Burden of Disease of Gonorrhoea in Latin America: Systematic Review and Meta-analysis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-02-28T09:51:06Z
dc.identifier.eissn
2193-6382
dc.journal.volume
12
dc.journal.number
6
dc.journal.pagination
1505-1525
dc.journal.pais
Alemania
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dc.journal.ciudad
Berlin
dc.description.fil
Fil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
dc.description.fil
Fil: Alconada, Tomás. Instituto de Efectividad Clínica y Sanitaria; Argentina
dc.description.fil
Fil: Palermo, Carolina. Instituto de Efectividad Clínica y Sanitaria; Argentina
dc.description.fil
Fil: Rojas Roque, Carlos. Instituto de Efectividad Clínica y Sanitaria; Argentina
dc.description.fil
Fil: Sandoval, María Macarena. Instituto de Efectividad Clínica y Sanitaria; Argentina
dc.description.fil
Fil: Gomez, Jorge. Gsk; Argentina
dc.description.fil
Fil: Pinto, Thatiana. Glaxosmithkline Plc.; Panamá
dc.description.fil
Fil: Ciapponi, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
dc.journal.title
Infectious Diseases and Therapy
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s40121-023-00814-0
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s40121-023-00814-0
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