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dc.contributor.author
Hafeez Kiani, Bushra
dc.contributor.author
Alonso, Maria Natalia
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dc.contributor.author
Weathers, Pamela J.
dc.contributor.author
Shell, Scarlet S.
dc.date.available
2024-02-28T11:56:35Z
dc.date.issued
2023-02
dc.identifier.citation
Hafeez Kiani, Bushra; Alonso, Maria Natalia; Weathers, Pamela J.; Shell, Scarlet S.; Artemisia afra and Artemisia annua Extracts Have Bactericidal Activity against Mycobacterium tuberculosis in Physiologically Relevant Carbon Sources and Hypoxia; MDPI; Pathogens; 12; 2; 2-2023; 1-12
dc.identifier.issn
2076-0817
dc.identifier.uri
http://hdl.handle.net/11336/228708
dc.description.abstract
Mycobacterium tuberculosis (Mtb) is a deadly pathogen and causative agent of human tuberculosis, causing ~1.5 million deaths every year. The increasing drug resistance of this pathogen necessitates novel and improved treatment strategies. A crucial aspect of the host–pathogen interaction is bacterial nutrition. In this study, Artemisia annua and Artemisia afra dichloromethane extracts were tested for bactericidal activity against Mtb strain mc26230 under hypoxia and various infection-associated carbon sources (glycerol, glucose, and cholesterol). Both extracts showed significant bactericidal activity against Mtb, regardless of carbon source. Based on killing curves, A. afra showed the most consistent bactericidal activity against Mtb for all tested carbon sources, whereas A. annua showed the highest bactericidal activity in 7H9 minimal media with glycerol. Both extracts retained their bactericidal activity against Mtb under hypoxic conditions. Further investigations are required to determine the mechanism of action of these extracts and identify their active constituent compounds.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
MDPI
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
ARTEMISIA AFRA
dc.subject
ARTEMISIA ANNUA
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ARTEMISININ
dc.subject
CARBON SOURCE
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CHOLESTEROL
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HYPOXIA
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MYCOBACTERIUM TUBERCULOSIS
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Artemisia afra and Artemisia annua Extracts Have Bactericidal Activity against Mycobacterium tuberculosis in Physiologically Relevant Carbon Sources and Hypoxia
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-02-28T10:34:12Z
dc.journal.volume
12
dc.journal.number
2
dc.journal.pagination
1-12
dc.journal.pais
Suiza
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dc.description.fil
Fil: Hafeez Kiani, Bushra. Worcester Polytechnic Institute; Estados Unidos
dc.description.fil
Fil: Alonso, Maria Natalia. Worcester Polytechnic Institute; Estados Unidos. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Agrobiotecnología y Biología Molecular. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Agrobiotecnología y Biología Molecular; Argentina
dc.description.fil
Fil: Weathers, Pamela J.. Worcester Polytechnic Institute; Estados Unidos
dc.description.fil
Fil: Shell, Scarlet S.. Worcester Polytechnic Institute; Estados Unidos
dc.journal.title
Pathogens
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2076-0817/12/2/227
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/pathogens12020227
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