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dc.contributor.author
Joray, Mariana Belén
dc.contributor.author
Palacios, Sara Maria
dc.contributor.author
Carpinella, Maria Cecilia
dc.date.available
2017-08-18T19:33:15Z
dc.date.issued
2012-12
dc.identifier.citation
Joray, Mariana Belén; Palacios, Sara Maria; Carpinella, Maria Cecilia; Understanding the interactions between metabolites isolated from Achyrocline satureioides in relation to its antibacterial activity; Elsevier Gmbh; Phytomedicine; 20; 3-4; 12-2012; 258-261
dc.identifier.issn
0944-7113
dc.identifier.uri
http://hdl.handle.net/11336/22689
dc.description.abstract
As part of our ongoing research on the antibacterial activity of Achyrocline satureioides, this study seeks to better understand the interactions between the metabolites isolated from this plant. For this purpose, the combined effect of 23-methyl-6-O-desmethylauricepyrone (1), quercetin (2) and 3-O-methylquercetin (3), obtained through bioguided fractionation from A. satureioides ethanol extract, was evaluated against Staphylococcus aureus and Escherichia coli. In first place, the antibacterial effect of the combination of flavonols 2 and 3 was assessed, as these showed individual effectiveness lower than or equal to that of the fraction from which they were obtained. When the flavonols were applied together at concentrations below their minimum inhibitory concentration (MIC) values, a synergistic effect (FICI < 0.30) against S. aureus was observed. In addition, compounds 2 and 3 in combination reduced 1000 times the MIC of compound 1, showing a clear synergistic interaction (FICI < 0.15) in treatments against the Gram (+) bacterium. The most active combination against E. coli showed an additive interaction (FICI < 0.62) between the three assayed compounds 1–3. These results indicated the existence of concerted action between these metabolites, evidence of the importance of the synergistic interactions between the components of plant-derived extracts for the control of pathogenic bacteria.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Gmbh
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Achyrocline Satureioides
dc.subject
Sinergismo
dc.subject
Antibacterianos
dc.subject.classification
Bioquímica y Biología Molecular
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Understanding the interactions between metabolites isolated from Achyrocline satureioides in relation to its antibacterial activity
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-08-18T14:59:15Z
dc.journal.volume
20
dc.journal.number
3-4
dc.journal.pagination
258-261
dc.journal.pais
Alemania
dc.description.fil
Fil: Joray, Mariana Belén. Universidad Católica de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Palacios, Sara Maria. Universidad Católica de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Carpinella, Maria Cecilia. Universidad Católica de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Phytomedicine
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.phymed.2012.10.015
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0944711312003819
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