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dc.contributor.author
Macirella, Rachele
dc.contributor.author
Curcio, Vittoria
dc.contributor.author
Ahmed, Abdalmoiz I. M.
dc.contributor.author
Talarico, Federica
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Sesti, Settimio
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Paravani, Enrique Valentin
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Odetti, Lucia Magdalena
dc.contributor.author
Mezzasalma, Marcello
dc.contributor.author
Brunelli, Elvira
dc.date.available
2024-01-26T15:41:42Z
dc.date.issued
2023-06
dc.identifier.citation
Macirella, Rachele; Curcio, Vittoria; Ahmed, Abdalmoiz I. M.; Talarico, Federica; Sesti, Settimio; et al.; Morphological and Functional Alterations in Zebrafish (Danio rerio) Liver after Exposure to Two Ecologically Relevant Concentrations of Lead; MDPI; Fishes; 8; 7; 6-2023; 1-17
dc.identifier.issn
2410-3888
dc.identifier.uri
http://hdl.handle.net/11336/225026
dc.description.abstract
Lead (Pb) is a non-essential, highly toxic, and persistent element widely recognized as one of the most concerning pollutants. It is listed on the Priority List of Hazardous Substances. Widespread environmental contamination from Pb is a serious issue for human health and wildlife. In fish, Pb mainly accumulates in the liver, which is a key component for metal detoxification and excretion processes. In this study, we investigated, for the first time, the morphological and functional injuries induced in zebrafish (Danio rerio) liver by two very low and environmentally relevant concentrations of Pb (2.5 and 5 μg/L) after 48, 96, and 192 h of exposure. We observed significant histological alterations in all the exposed samples, and it was demonstrated that the extent of injuries increased with dose and exposure time. The most common modifications observed were congestion of blood vessels and sinusoids, cytoplasmic vacuolizations, parenchyma dyschromia, and macrophage proliferation. Pb administration also resulted in a significant increase in lipid content and the upregulation of key genes that are involved in metal detoxification (mtf1) and the defensive response against oxidative stress (sod1 and cat). We show that even very low doses of Pb can disrupt liver morphology and function.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
MDPI
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
CAT
dc.subject
HISTOLOGICAL BIOMARKERS
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LIVER
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MOLECULAR BIOMARKERS
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MTS
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PB
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SOD
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Otros Tópicos Biológicos
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Morphological and Functional Alterations in Zebrafish (Danio rerio) Liver after Exposure to Two Ecologically Relevant Concentrations of Lead
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-01-26T11:09:45Z
dc.journal.volume
8
dc.journal.number
7
dc.journal.pagination
1-17
dc.journal.pais
Suiza
dc.description.fil
Fil: Macirella, Rachele. Università della Calabria; Italia
dc.description.fil
Fil: Curcio, Vittoria. Università della Calabria; Italia
dc.description.fil
Fil: Ahmed, Abdalmoiz I. M.. Università della Calabria; Italia
dc.description.fil
Fil: Talarico, Federica. Università della Calabria; Italia
dc.description.fil
Fil: Sesti, Settimio. Università della Calabria; Italia
dc.description.fil
Fil: Paravani, Enrique Valentin. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; Argentina
dc.description.fil
Fil: Odetti, Lucia Magdalena. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Cátedra de Toxicología y Bioquímica Legal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
dc.description.fil
Fil: Mezzasalma, Marcello. Università della Calabria; Italia
dc.description.fil
Fil: Brunelli, Elvira. Università della Calabria; Italia
dc.journal.title
Fishes
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2410-3888/8/7/342
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/fishes8070342
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