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dc.contributor.author
Pirola, Carlos José
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dc.contributor.author
Sookoian, Silvia Cristina
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dc.date.available
2023-12-12T12:06:31Z
dc.date.issued
2023-06
dc.identifier.citation
Pirola, Carlos José; Sookoian, Silvia Cristina; Non‐alcoholic fatty liver disease mediates the effect of obesity on arterial hypertension; Wiley Blackwell Publishing, Inc; Liver International; 43; 10; 6-2023; 2167-2176
dc.identifier.issn
1478-3223
dc.identifier.uri
http://hdl.handle.net/11336/219920
dc.description.abstract
Background: It has been consistently shown that obesity contributes directly to arterial hypertension and cardiovascular disease (CVD), independently of other risk factors. Likewise, non-alcoholic fatty liver disease (NAFLD) is acknowledged as a contributor and a risk enhancer for CVD. Objectives: We tested the hypothesis of a causal role of NAFLD in the effect of obesity on arterial hypertension. Methods: Using causal mediation analysis, we quantified the magnitude of the body mass index (BMI) effect on arterial hypertension and CV-traits mediated by NAFLD. First, we analysed data from 1348 young adults in the Bogalusa Heart Study (BHS), a cohort aimed at assessing the natural history of CVD. Then, we used data from 3359 participants of the National Health and Nutrition Examination Survey (2017–2018 cycle, NHANES) to replicate the findings. Results: We found that roughly 92% of the effects of BMI on arterial hypertension in the BHS and 51% in the NHANES population are mediated by NAFLD. In addition, indirect effects of BMI on systolic (SBP) and diastolic (DBP) blood pressure, and heart rate (HR) through NAFLD explained up to 91%, 93%, and 100% of the total effect, respectively, in the BHS. In the NHANES survey, indirect effects of BMI through NAFLD on CV traits explain a significant proportion of the total effects (SBP = 60.4%, HR = 100%, and pulse pressure = 88%). Conclusion: NAFLD mediates a substantial proportion of the effect of obesity on the presence of hypertension and CV-parameters independently of relevant covariates. This conclusion has implications for clinical management.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ARTERIAL HYPERTENSION
dc.subject
CARDIOVASCULAR RISK
dc.subject
NAFLD
dc.subject
NASH
dc.subject
OBESITY
dc.subject.classification
Gastroenterología y Hepatología
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Non‐alcoholic fatty liver disease mediates the effect of obesity on arterial hypertension
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-12-11T18:00:49Z
dc.journal.volume
43
dc.journal.number
10
dc.journal.pagination
2167-2176
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Pirola, Carlos José. Universidad Abierta Interamericana. Facultad de Medicina. Centro de Altos Estudios en Ciencias de la Salud; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Sookoian, Silvia Cristina. Universidad Abierta Interamericana. Secretaría de Investigación. Centro de Altos Estudios En Ciencias Humanas y de la Salud - Sede Buenos Aires.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Maimónides; Argentina
dc.journal.title
Liver International
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/liv.15643
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/liv.15643
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