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dc.contributor.author
Gauffin Cano, María Paola  
dc.contributor.author
Santacruz, Arlette  
dc.contributor.author
Trejo, Fernando M.  
dc.contributor.author
Sanz, Yolanda  
dc.date.available
2015-09-29T19:58:25Z  
dc.date.issued
2013-11  
dc.identifier.citation
Gauffin Cano, María Paola; Santacruz, Arlette; Trejo, Fernando M.; Sanz, Yolanda; Bifidobacterium CECT 7765 improves metabolic and immunological dysfunction associated with obesity in high-fat diet fed mice; John Wiley & Sons Inc; Obesity; 21; 11; 11-2013; 2310-2321  
dc.identifier.issn
1930-7381  
dc.identifier.uri
http://hdl.handle.net/11336/2183  
dc.description.abstract
Objectives: To evaluate the effects of administration of Bifidobacterium pseudocatenulatum CECT 7765 on metabolic and immune alterations in obese mice. Design and Methods: Adult male wild-type C57BL-6 mice were fed a standard diet or high-fat diet (HFD), supplemented or not with B. pseudocatenulatum CECT 7765 for 7 weeks. The assessments included biochemical and immunological parameters, insulin resistance, glucose tolerance, histology of liver, white-adipose and intestinal tissues, immunocompetent cell functions, and microbiota-related features. Results: B. pseudocatenulatum CECT 7765 reduced serum cholesterol, triglyceride, and glucose levels and decreased insulin resistance and improved glucose tolerance in obese mice. This strain reduced serum levels of leptin, interleukin (IL)-6 and monocyte chemotactic protein-1, while increased those of IL-4 in HFD-fed mice. B. pseudocatenulatum CECT7765 reduced liver steatosis and the number of larger adipocytes and number of fat micelles in enterocytes of obese mice. The strain also improved the function of macrophages and dendritic cells in relation to phagocytosis, cytokine production, and induction of T-lymphocyte proliferation. The strain administration increased bifidobacteria and reduced enterobacteria and the inflammatory properties of the gut content in HFD-fed mice. Conclusion: B. pseudocatenulatum CECT 7765 was shown to ameliorate both metabolic and immunological dysfunctions related to obesity in HFD-fed mice.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
John Wiley & Sons Inc  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Obesity  
dc.subject
Imunological Function  
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Metabolic Parameters  
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Gut Microbiota  
dc.subject.classification
Otras Biotecnologías de la Salud  
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Biotecnología de la Salud  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Bifidobacterium CECT 7765 improves metabolic and immunological dysfunction associated with obesity in high-fat diet fed mice  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2016-03-30 10:35:44.97925-03  
dc.journal.volume
21  
dc.journal.number
11  
dc.journal.pagination
2310-2321  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Londres  
dc.description.fil
Fil: Gauffin Cano, María Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia para Lactobacilos (i); Argentina  
dc.description.fil
Fil: Santacruz, Arlette. Consejo Superior de Investigaciones Científicas. Instituto de Agroquímica y Tecnología de Alimentos; España  
dc.description.fil
Fil: Trejo, Fernando M.. Consejo Superior de Investigaciones Científicas. Instituto de Agroquímica y Tecnología de Alimentos; España  
dc.description.fil
Fil: Sanz, Yolanda. Consejo Superior de Investigaciones Científicas. Instituto de Agroquímica y Tecnología de Alimentos; España  
dc.journal.title
Obesity  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1930-739X  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/oby.20330