Mitochondrial dysfunction and Inflammatory Responses

Abstract

Exaggerated oxidative stress and hyper-inflammation are essential features of oxidative/inflammatorydiseases. Simultaneously, both processes may be the cause or consequence of mitochondrialdysfunction, thus establishing a vicious cycle among these three factors. However, several naturalsubstances, including melatonin and micronutrients, may prevent or attenuate mitochondrial damageand may preserve an optimal state of health by managing the general oxidative and inflammatorystatus.