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Artículo

Does Vitamin D Insufficiency Influence Prebiotic Effect on Calcium Absorption and Bone Retention?

Seijo, MarianaIcon ; Bonanno, Marina SoledadIcon ; Bryk, Gabriel; Zeni Coronel, Estefania MagaliIcon ; Pita Martín de Portela, María Luz; Zeni, Susana NoemiIcon
Fecha de publicación: 09/2022
Editorial: Springer
Revista: Calcified Tissue International
ISSN: 0171-967X
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Medicina Básica

Resumen

Higher calcium (Ca) absorption would partially compensate for Ca intake below requirements for bone health. Previously, we found that GOS/FOS prebiotic mixture (PM) increases Ca absorption in the colon and retention in bone. Ca absorption and retention are regulated by vitamin D (VD). Hence, it is relevant to explore whether VD insufficiency influences the effect of the PM in the colon. The effect of the PM on Ca, phosphate (IP), and magnesium (Mg) absorption and retention under conditions of VD sufficiency and insufficiency (VDInsuff) was compared using a preclinical model of VDInsuff and low bone mass. Ovariectomized rats were fed isocaloric semisynthetic diets according to AIN-93 M. The diets varied in Ca (0.5% or 0.3%), VD [100 IU% (+ D) or 0 IU% (− D)], and PM (2.5% or 0%) content. The following eight groups were studied: + D0.5; + D0.3; + DPM0.5; + DPM0.3; − D0.5; − D0.3; − DPM0.5; and − DPM0.3. Irrespective of Ca content, VDInsuff did not affect the prebiotic effect of the PM on caecum pH, lactobacillus colony growth, or Mg absorption but significantly decreased its effect on colonic crypt length and cell/crypt and Ca and IP absorption. The PM failed to counterbalance the pro-inflammatory effect of VDInsuff. Moreover, bone retention i.e., bone mineral content and density, bone volume, and bone quality parameters were significantly lower (p < 0.05) and bone turnover significantly was higher (p < 0.05). Although the PM is a useful tool to improve mineral absorption and bone retention, it would seem important to monitor VD nutritional status to ensure the full prebiotic effect in the large intestine.
Palabras clave: CALCIUM AND PHOSPHATE ABSORPTION AND RETENTION , PREBIOTICS , RATS , VITAMIN D
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/208539
DOI: http://dx.doi.org/10.1007/s00223-022-00984-y
URL: https://link.springer.com/article/10.1007/s00223-022-00984-y
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Articulos(INIGEM)
Articulos de INSTITUTO DE INMUNOLOGIA, GENETICA Y METABOLISMO
Citación
Seijo, Mariana; Bonanno, Marina Soledad; Bryk, Gabriel; Zeni Coronel, Estefania Magali; Pita Martín de Portela, María Luz; et al.; Does Vitamin D Insufficiency Influence Prebiotic Effect on Calcium Absorption and Bone Retention?; Springer; Calcified Tissue International; 111; 3; 9-2022; 300-312
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