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Artículo

Immune response and serum bactericidal activity against Brucella ovis elicited using a short immunization schedule with the polymeric antigen BLSOmp31 in rams.

Díaz, Alejandra GracielaIcon ; Clausse, MaríaIcon ; Paolicchi, Fernando Alberto; Fiorentino, Maria AndreaIcon ; Ghersi, GiselleIcon ; Zylberman, VanesaIcon ; Goldbaum, Fernando AlbertoIcon ; Estein, Silvia MarcelaIcon
Fecha de publicación: 04/2013
Editorial: Elsevier Science
Revista: Veterinary Immunology And Immunopathology
ISSN: 0165-2427
e-ISSN: 1873-2534
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Biología Celular, Microbiología

Resumen

Brucella ovis is the etiologic agent of ovine brucellosis. The control measures for this disease are periodical diagnosis by serological tests and/or bacteriological culture and culling of positive animals. Vaccination with Brucella melitensis Rev 1 is recommended when prevalence is high. This attenuated strain vaccine gives protection against B. ovis but it has important disadvantages associated with the development of antibodies interfering with serodiagnosis, virulence for humans and the prohibition of its use in countries considered free of B. melitensis. Consequently, there is a need for new safe and effective brucellosis vaccines to be developed. We have previously reported that the polymeric subcellular vaccine BLSOmp31 confers protection against experimental challenge with B. ovis when rams are immunized three times. In the present work we evaluated and characterized, along 56 weeks after the first immunization of adult rams, the evolution of the immune response elicited by BLSOmp31 using a short immunization schedule.
Palabras clave: Chimera Blsomp31 , Ram , Immune Response , Short Immunization Schedule
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/20604
URL: http://www.sciencedirect.com/science/article/pii/S0165242713001232
DOI: https://doi.org/10.1016/j.vetimm.2013.04.003
Colecciones
Articulos(CCT - TANDIL)
Articulos de CTRO CIENTIFICO TECNOLOGICO CONICET - TANDIL
Articulos(CIVETAN)
Articulos de CENTRO DE INVESTIGACION VETERINARIA DE TANDIL
Articulos(IIBBA)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Citación
Díaz, Alejandra Graciela; Clausse, María; Paolicchi, Fernando Alberto; Fiorentino, Maria Andrea; Ghersi, Giselle; et al.; Immune response and serum bactericidal activity against Brucella ovis elicited using a short immunization schedule with the polymeric antigen BLSOmp31 in rams.; Elsevier Science; Veterinary Immunology And Immunopathology; 154; 1-2; 4-2013; 36-41
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