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dc.contributor.author
Kornblihtt, Alberto Rodolfo  
dc.date.available
2017-07-13T18:31:58Z  
dc.date.issued
2012-02  
dc.identifier.citation
Kornblihtt, Alberto Rodolfo; CTCF: from insulators to alternative splicing regulation; Nature Publishing Group; Cell Research; 22; 2-2012; 450-452  
dc.identifier.issn
1001-0602  
dc.identifier.uri
http://hdl.handle.net/11336/20371  
dc.description.abstract
The zinc-finger DNA-binding protein CTCF has been known for being a constituent of insulators. A recent paper in Nature reports an unforeseen intragenic role for CTCF that links DNA methylation with alternative splicing. By binding to its target DNA site placed within an alternative exon, CTCF creates a roadblock to transcriptional elongation that favors inclusion of the exon into mature mRNA. DNA methylation prevents CTCF binding, which releases pol II transient blockage and promotes exon exclusion.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Nature Publishing Group  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Ctcf  
dc.subject
Splicing  
dc.subject.classification
Bioquímica y Biología Molecular  
dc.subject.classification
Ciencias Biológicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
CTCF: from insulators to alternative splicing regulation  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2017-07-12T14:51:08Z  
dc.identifier.eissn
1748-7838  
dc.journal.volume
22  
dc.journal.pagination
450-452  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Londres  
dc.description.fil
Fil: Kornblihtt, Alberto Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina  
dc.journal.title
Cell Research  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/cr.2012.22  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/cr/journal/v22/n3/full/cr201222a.html  

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