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dc.contributor.author
Otero, L. L.  
dc.contributor.author
Alonso, Daniel Fernando  
dc.contributor.author
Castro, M.  
dc.contributor.author
Cinat, G.  
dc.contributor.author
Gabri, M. R.  
dc.contributor.author
Gomez, Daniel Eduardo  
dc.date.available
2023-03-29T12:15:06Z  
dc.date.issued
2011-02  
dc.identifier.citation
Otero, L. L.; Alonso, Daniel Fernando; Castro, M.; Cinat, G.; Gabri, M. R.; et al.; Tissue factor as a novel marker for detection of circulating cancer cells; Taylor & Francis Ltd; Biomarkers; 16; 1; 2-2011; 58-64  
dc.identifier.issn
1354-750X  
dc.identifier.uri
http://hdl.handle.net/11336/191950  
dc.description.abstract
Tissue factor (TF) is a molecular marker that is up-regulated in cancer cells and aids tumoral dissemination. Our purpose was to develop a nested RT-PCR strategy against TF for detecting blood-borne tumour cells. Our method detected TF expression in a minimum of 1.5 pg total RNA from MCF7 cells. A preliminary study in blood samples from 16 advanced breast carcinoma patients showed that 80% of patients with high TF load progressed and died, while only 18% with low TF load showed the same behaviour. Kaplan-Meier analysis confirmed worse overall survival in patients with high TF load.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Taylor & Francis Ltd  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
BIOMARKER  
dc.subject
BREAST CANCER  
dc.subject
NESTED PCR  
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RT-PCR  
dc.subject
TISSUE FACTOR  
dc.subject.classification
Oncología  
dc.subject.classification
Medicina Clínica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Tissue factor as a novel marker for detection of circulating cancer cells  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2023-03-28T14:09:59Z  
dc.journal.volume
16  
dc.journal.number
1  
dc.journal.pagination
58-64  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Londres  
dc.description.fil
Fil: Otero, L. L.. Universidad Nacional de Quilmes; Argentina  
dc.description.fil
Fil: Alonso, Daniel Fernando. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Castro, M.. Universidad de Buenos Aires; Argentina  
dc.description.fil
Fil: Cinat, G.. Universidad de Buenos Aires; Argentina  
dc.description.fil
Fil: Gabri, M. R.. Universidad Nacional de Quilmes; Argentina  
dc.description.fil
Fil: Gomez, Daniel Eduardo. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.journal.title
Biomarkers  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.3109/1354750X.2010.533282?journalCode=ibmk20  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3109/1354750X.2010.533282  

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