Artículo

Tissue factor as a novel marker for detection of circulating cancer cells

Otero, L. L.; Alonso, Daniel FernandoIcon ; Castro, M.; Cinat, G.; Gabri, M. R.; Gomez, Daniel EduardoIcon
Fecha de publicación: 02/2011
Editorial: Taylor & Francis Ltd
Revista: Biomarkers
ISSN: 1354-750X
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

Tissue factor (TF) is a molecular marker that is up-regulated in cancer cells and aids tumoral dissemination. Our purpose was to develop a nested RT-PCR strategy against TF for detecting blood-borne tumour cells. Our method detected TF expression in a minimum of 1.5 pg total RNA from MCF7 cells. A preliminary study in blood samples from 16 advanced breast carcinoma patients showed that 80% of patients with high TF load progressed and died, while only 18% with low TF load showed the same behaviour. Kaplan-Meier analysis confirmed worse overall survival in patients with high TF load.
Palabras clave: BIOMARKER , BREAST CANCER , NESTED PCR , RT-PCR , TISSUE FACTOR
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/191950
URL: https://www.tandfonline.com/doi/abs/10.3109/1354750X.2010.533282?journalCode=ibm
DOI: http://dx.doi.org/10.3109/1354750X.2010.533282
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Citación
Otero, L. L.; Alonso, Daniel Fernando; Castro, M.; Cinat, G.; Gabri, M. R.; et al.; Tissue factor as a novel marker for detection of circulating cancer cells; Taylor & Francis Ltd; Biomarkers; 16; 1; 2-2011; 58-64
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