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dc.contributor.author
Denninghoff, Valeria Cecilia
dc.contributor.other
Strumfa, Ilze
dc.date.available
2023-02-23T17:59:27Z
dc.date.issued
2021
dc.identifier.citation
Denninghoff, Valeria Cecilia; Molecular Pathology in the New Age of Personalized Medicine; IntechOpen; 2021; 1-16
dc.identifier.isbn
978-1-83881-859-3
dc.identifier.uri
http://hdl.handle.net/11336/188748
dc.description.abstract
Personalized medicine is a new approach that allows the identification ofpatients that can benefit from targeted therapies because of the molecular characteristicsof the tumors they present. The molecular profile of the tumor can bestudied at the genomic (DNA), transcriptomic (RNA) or protein (protein) level.The next generation sequencing is a useful tool for the study of molecular profilefrom DNA/RNA. This tool requires molecular pathologists highly trained in preanalyticprocesses, tumor area microdissection for tumor cell enrichment, methodologyanalysis and results. The in-depth study of molecular alterations in patientsallows optimizing molecular diagnosis and selecting candidates for receive noveltreatments against specific molecular targets. These patients are expected to benefitfrom multidisciplinary approach and learning. The aim of this chapter is to showthe implications of molecular pathology in personalized medicine with an actualapproach from the methodological limitations of formalin-fixed paraffin embedded(FFPE) tissues and their pre-analytical conditions.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
IntechOpen
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
molecular pathology
dc.subject
personalized medicine
dc.subject
next generation sequencing, NGS
dc.subject
multidisciplinary approach
dc.subject.classification
Tecnologías que involucran la identificación de ADN, proteínas y enzimas, y cómo influyen en el conjunto de enfermedades y mantenimiento del bienestar
dc.subject.classification
Biotecnología de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Molecular Pathology in the New Age of Personalized Medicine
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/bookPart
dc.type
info:ar-repo/semantics/parte de libro
dc.date.updated
2023-02-16T15:48:36Z
dc.journal.pagination
1-16
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Denninghoff, Valeria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.5772/intechopen.94927
dc.conicet.paginas
100
dc.source.titulo
Pathology: From Classics to Innovations
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