Repositorio Institucional
Repositorio Institucional
CONICET Digital
  • Inicio
  • EXPLORAR
    • AUTORES
    • DISCIPLINAS
    • COMUNIDADES
  • Estadísticas
  • Novedades
    • Noticias
    • Boletines
  • Ayuda
    • General
    • Datos de investigación
  • Acerca de
    • CONICET Digital
    • Equipo
    • Red Federal
  • Contacto
JavaScript is disabled for your browser. Some features of this site may not work without it.
  • INFORMACIÓN GENERAL
  • RESUMEN
  • ESTADISTICAS
 
Artículo

Preventive effects of the antioxidant and antigenotoxic Achyrocline satureioides extract against zearalenone-induced mammal cytogenotoxicity and histological damage

Sabini, Maria CarolaIcon ; Cariddi, Laura NoeliaIcon ; Escobar, Franco MatiasIcon ; Mañas, Fernando JavierIcon ; Roma, Dardo AndrésIcon ; Menis Candela, FlorenciaIcon ; Bagnis, Guillermo; Soria, Elio AndresIcon ; Sabini, Liliana Ines; Dalcero, Ana MariaIcon
Fecha de publicación: 01/2021
Editorial: Wageningen Academic Publishers
Revista: World Mycotoxin Journal
ISSN: 1875-0710
e-ISSN: 1875-0796
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Micología

Resumen

Zearalenone (ZEN), a Fusarium s mycotoxin, is immunotoxic, genotoxic, hepatonephrotoxic and, affects the reproductive system. ZEN induces toxic and genotoxic effects on humans and other animals. Achyrocline satureioides has several medicinal properties. Moreover, the aqueous extract of A. satureioides is a safe agent that exerts low cytotoxicity and no genotoxicity. This extract is a promissory candidate to counteract ZEN effects. The present study aimed to investigate the capacity of cold aqueous extract from A. satureioides to protect against ZEN multi-target toxicity in different experimental mammal models. Anticytotoxicity was evaluated by neutral red uptake and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium reduction assays. Comet assay and micronuclei test, oxidative stress (TBARs), and histopathological damage were evaluated in Balb/C mice. Anticytotoxic studies indicated that cold aqueous extract (100 and 300 μg/ml) protected from damage induced by ZEN (50 μg/ml) on Vero cells. In vivo studies indicated that ZEN (40 mg/kg body weight) induced an increase of genotoxicity: Micronuclei (34 MNPCE/1000 PCE) and increase of damage (tail moment) in blood cells. Also, it increased lipid peroxidation in liver and kidneys and generated several histopathological alterations in both organs. Cold aqueous extract (100 mg/kg body weight) protected from genotoxicity induced by ZEN in both tests. Cold aqueous extract, also, reduced the lipid peroxidation and histopathological damage in liver and kidneys. In conclusion, the cold aqueous extract of A. satureioides that contains bioactive flavonoids prevents the multi-target toxicity induced by ZEN improving all the parameters evaluated in vitro and in vivo, which is a valuable and original finding in order to develop future treatments for human and veterinary medicine.
Palabras clave: ACHYROCLINE SATUREIOIDES , ZEARALENONE , CYTOTOXICITY , GENOTOXICITY , DETOXIFICATION
Ver el registro completo
 
Archivos asociados
Tamaño: 1.132Mb
Formato: PDF
.
Solicitar
Licencia
info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/183544
DOI: https://doi.org/10.3920/WMJ2020.2571
URL: https://www.wageningenacademic.com/doi/10.3920/WMJ2020.2571
Colecciones
Articulos (INCIVET)
Articulos de INSTITUTO DE CIENCIAS VETERINARIAS
Articulos(INICSA)
Articulos de INSTITUTO DE INVESTIGACIONES EN CIENCIAS DE LA SALUD
Citación
Sabini, Maria Carola; Cariddi, Laura Noelia; Escobar, Franco Matias; Mañas, Fernando Javier; Roma, Dardo Andrés; et al.; Preventive effects of the antioxidant and antigenotoxic Achyrocline satureioides extract against zearalenone-induced mammal cytogenotoxicity and histological damage; Wageningen Academic Publishers; World Mycotoxin Journal; 14; 3; 1-2021; 401-409
Compartir
Altmétricas
 

Enviar por e-mail
Separar cada destinatario (hasta 5) con punto y coma.
  • Facebook
  • X Conicet Digital
  • Instagram
  • YouTube
  • Sound Cloud
  • LinkedIn

Los contenidos del CONICET están licenciados bajo Creative Commons Reconocimiento 2.5 Argentina License

https://www.conicet.gov.ar/ - CONICET

Inicio

Explorar

  • Autores
  • Disciplinas
  • Comunidades

Estadísticas

Novedades

  • Noticias
  • Boletines

Ayuda

Acerca de

  • CONICET Digital
  • Equipo
  • Red Federal

Contacto

Godoy Cruz 2290 (C1425FQB) CABA – República Argentina – Tel: +5411 4899-5400 repositorio@conicet.gov.ar
TÉRMINOS Y CONDICIONES