Mostrar el registro sencillo del ítem
dc.contributor.author
Loscalzo, Leonardo Martin
dc.contributor.author
Yow, Tin T.
dc.contributor.author
Wasowski, Cristina Lucia N.
dc.contributor.author
Chebib, Mary
dc.contributor.author
Marder, Nora Mariel
dc.date.available
2017-06-14T18:51:16Z
dc.date.issued
2011-09
dc.identifier.citation
Loscalzo, Leonardo Martin; Yow, Tin T.; Wasowski, Cristina Lucia N.; Chebib, Mary; Marder, Nora Mariel; Hesperidin induces antinociceptive effect in mice and its aglicone, hesperetin, binds to mu-opioid; Elsevier Inc; Pharmacology Biochemistry And Behavior; 99; 3; 9-2011; 333-341
dc.identifier.issn
0091-3057
dc.identifier.uri
http://hdl.handle.net/11336/18187
dc.description.abstract
This paper extended the evaluation of the depressant and antinociceptive activities of hesperidin in order to determine its effectiveness by the intraperitoneal and oral routes, its pharmacological interaction with diverse pathways of neurotransmission and the role of its aglycone, hesperetin. The capacity of hesperidin and hesperetin to bind to μ-opioid receptor and their actions on μ-opioid receptor co-expressed with GIRK1/GIRK2 channels (G protein-activated inwardly rectifying K+ channels) in Xenopus laevis oocytes were also determined. Hesperidin exhibited a depressant activity in the hole board and locomotor activity tests, antinociceptive activities in the abdominal writhing and hot plate tests and no motor incoordination in the inverted screen and rotarod assays, only by the intraperitoneal route. Hesperetin did not show any effects in vivo in mice in these models, but in vitro it displaced the [3H]DAMGO binding with low-affinity and inhibited inward currents through the expressed GIRK1/2 channels. Although hesperidin actions in vivo demonstrated to be mediated by an opioid mechanism of action, it failed to directly bind to and activate the μ-opioid receptor or produce any change on inward GIRK1/2 currents in vitro. However, it should be considered that hesperidin may be metabolized, possibly resulting in crucial changes in its biological activity.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Hesperidin
dc.subject
Hesperetin
dc.subject
Depressant
dc.subject
Antinociception
dc.subject
Mu-Opioid Receptor
dc.subject
Xenopus Oocytes
dc.subject.classification
Bioquímica y Biología Molecular
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Hesperidin induces antinociceptive effect in mice and its aglicone, hesperetin, binds to mu-opioid
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-06-14T14:34:26Z
dc.journal.volume
99
dc.journal.number
3
dc.journal.pagination
333-341
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Loscalzo, Leonardo Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina. University of Sidney; Australia
dc.description.fil
Fil: Yow, Tin T.. University of Sidney; Australia
dc.description.fil
Fil: Wasowski, Cristina Lucia N.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
dc.description.fil
Fil: Chebib, Mary. University of Sidney; Australia
dc.description.fil
Fil: Marder, Nora Mariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
dc.journal.title
Pharmacology Biochemistry And Behavior
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0091305711001602
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.pbb.2011.05.018
Archivos asociados