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dc.contributor.author
Perdigon, Gabriela del Valle
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dc.contributor.author
Castillo, Natalia Alejandra
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dc.contributor.author
Maldonado Galdeano, María Carolina
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dc.contributor.author
de Moreno, Maria Alejandra
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dc.date.available
2015-08-25T13:49:05Z
dc.date.issued
2013-11
dc.identifier.citation
Perdigon, Gabriela del Valle; Castillo, Natalia Alejandra; Maldonado Galdeano, María Carolina; de Moreno, Maria Alejandra; Probiotics as protective agents against Enterobacteria; Karger; Annals Of Nutrition And Metabolism; 63; Supl.1-13; 11-2013; 6-7
dc.identifier.issn
0250-6807
dc.identifier.uri
http://hdl.handle.net/11336/1806
dc.description.abstract
Salmonella is one of the major causative agents of foodborne
diseases, morbidity and mortality worldwide. Salmonella
enterica serovar typhimurium(S. typhimurium) produces in
mice an infection with similar pathogenesis and clinical manifestations
than S. typhiin humans. Probiotics influence the
innate and adaptive immunity and the activity of the intestinal
microbiota. This knowledge allowed us to propose the use
of probiotic bacteria against Salmonella infection. On this topic,
the mechanisms mediating this protection are not yet established.
We determine the effect of the oral administration
of probiotic bacterium L. casei CRL-431 on the biological and
immune mechanisms involved in the prevention and treatment
of the S. Typhimurium infection, using BALB/c mice. Oral administration
of probiotic to healthy mice, induced activation of
gut immune cells in a regulated state. The continuous L. casei CRL-431 administration (previous and post-infection) protected
mice challenged with S. Typhimurium. The mechanisms
involved were: a) The modulation of innate immune response
by increased TLR expression on epithelial and immune cells.
b) Epithelial cell activation, evidenced by increases in secretion
of IL-6 and MCP-1. c) Increased number of macrophages,
dendritic cells and IgA (+) cells in lamina propria of the small
intestine, and increased secretion of total S-IgA. d)Reduction
of inflammation, with reduced TNF-alpha levels and myeloperoxidase
activity, less PMN infiltration in lamina propria
and regulation by IL-10. e)Increased phagocytic activity in
macrophage isolated from Peyer’s patches, spleen and peritoneum,
correlated with an increase of IFNgamma. The results
showed that L. casei CRL-431 induces biological and immune
mechanisms, which confer resistance to S. typhimuriuminfection,
showing lesser severity of the infection. The safety of
continuous administration of this probiotc strain, allows us to
suggest its use as an adjuvant of the mucosal immune system in
the prevention, and during Salmonella infection.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Karger
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.source
20th International Congress of Nutrition: Granada, Sept 15-20; Spain.; 2013
dc.subject
Probiotics
dc.subject
Mucosal Immunity
dc.subject
Enteropathogen
dc.subject
Salmonella
dc.subject.classification
Inmunología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Probiotics as protective agents against Enterobacteria
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.journal.volume
63
dc.journal.number
Supl.1-13
dc.journal.pagination
6-7
dc.journal.pais
Suiza
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dc.description.fil
Fil: Perdigon, Gabriela del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - CONICET - Tucumán. Centro de Referencia Para Lactobacilos (i); Argentina;
dc.description.fil
Fil: Castillo, Natalia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - CONICET - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos (i); Argentina;
dc.description.fil
Fil: Maldonado Galdeano, María Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - CONICET - Tucumán. Centro de Referencia Para Lactobacilos (i); Argentina;
dc.description.fil
Fil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - CONICET - Tucumán. Centro de Referencia Para Lactobacilos (i); Argentina;
dc.journal.title
Annals Of Nutrition And Metabolism
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dc.relation.isreferencedin
info:eu-repo/semantics/reference es info:eu-repo/semantics/reference/isbn/e–ISBN 978–3–318–02516–3
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://scholar.google.com/scholar?hl=es&as_sdt=0,5&cluster=15198957531234677468
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