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dc.contributor.author
Rodrigues Dos Passos Junior, Rinaldo
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Alves de Freitas, Raiany
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Reppetti, Julieta
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Medina Mora, Yollyseth Astrid
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Dela Justina, Vanessa
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Werle Bach, Camila
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Facholi Bomfim, Gisele
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Vitorino Lima, Victor
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Damiano, Alicia Ermelinda
dc.contributor.author
Gianchini, Fernanda
dc.date.available
2022-10-06T16:48:50Z
dc.date.issued
2021-06
dc.identifier.citation
Rodrigues Dos Passos Junior, Rinaldo; Alves de Freitas, Raiany; Reppetti, Julieta; Medina Mora, Yollyseth Astrid; Dela Justina, Vanessa; et al.; High Levels of Tumor Necrosis Factor-Alpha Reduce Placental Aquaporin 3 Expression and Impair in vitro Trophoblastic Cell Migration; Frontiers Media; Frontiers in Physiology; 12; 6-2021; 1-10
dc.identifier.issn
1664-042X
dc.identifier.uri
http://hdl.handle.net/11336/172284
dc.description.abstract
Placentas from preeclamptic women display augmented tumor necrosis factor-alpha (TNF-α) levels with reduced expression of aquaporin 3 (AQP3). However, whether TNF-α modulates AQP3 expression remains to be elucidated. We hypothesize that elevated levels of TNF-α reduce AQP3 expression and negatively impact trophoblastic cell migration. Spontaneously hypertensive rats (SHRs) and Wistar rats (14–16 weeks) were divided into hypertensive and normotensive groups, respectively. Systolic blood pressure (SBP) was measured, and animals mated. In a third group, pregnant SHRs were treated with a TNF-α antagonist, etanercept (0.8 mg/kg, subcutaneously) on days 0, 6, 12, and 18 of pregnancy. Placentas were collected on the 20th day of pregnancy. Human placental explants, from normotensive pregnancies, were incubated with TNF-α (5, 10, and 20 ng/ml) and/or etanercept (1 μg/ml). Swan 71 cells were incubated with TNF-α (10 ng/ml) and/or etanercept (1 μg/ml) and subjected to the wound healing assay. AQP3 expression was assessed by Western blot and TNF-α levels by ELISA. SBP (mmHg) was elevated in the hypertensive group, and etanercept treatment reduced this parameter. Placental TNF-α levels (pg/ml) were higher in the hypertensive group. AQP3 expression was reduced in the hypertensive group, and etanercept treatment reversed this parameter. Explants submitted to TNF-α exposition displayed reduced expression of AQP3, and etanercept incubation reversed it. Trophoblastic cells incubated with TNF-α showed decreased cell migration and reduced AQP3 expression, and etanercept incubation ameliorated it. Altogether, these data demonstrate that high TNF-α levels negatively modulate AQP3 in placental tissue, impairing cell migration, and its relationship in a pregnancy affected by hypertension.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Frontiers Media
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
HYPERTENSIVE PREGNANCY
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MIGRATION
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PLACENTA
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PREECLAMPSIA
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TROPHOBLASTIC CELL
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Patología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
High Levels of Tumor Necrosis Factor-Alpha Reduce Placental Aquaporin 3 Expression and Impair in vitro Trophoblastic Cell Migration
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-09-20T15:48:53Z
dc.journal.volume
12
dc.journal.pagination
1-10
dc.journal.pais
Suiza
dc.description.fil
Fil: Rodrigues Dos Passos Junior, Rinaldo. Universidade Federal de Goiás; Brasil
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Fil: Alves de Freitas, Raiany. Universidade Federal de Goiás; Brasil
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Fil: Reppetti, Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina
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Fil: Medina Mora, Yollyseth Astrid. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina
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Fil: Dela Justina, Vanessa. Universidade Federal de Goiás; Brasil
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Fil: Werle Bach, Camila. Universidade Federal do Mato Grosso do Sul; Brasil
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Fil: Facholi Bomfim, Gisele. Universidade Federal do Mato Grosso do Sul; Brasil
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Fil: Vitorino Lima, Victor. Universidade Federal do Mato Grosso do Sul; Brasil
dc.description.fil
Fil: Damiano, Alicia Ermelinda. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina
dc.description.fil
Fil: Gianchini, Fernanda. Universidade Federal de Goiás; Brasil
dc.journal.title
Frontiers in Physiology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fphys.2021.696495/full
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fphys.2021.696495
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