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dc.contributor.author
Martinez Moro, Marta
dc.contributor.author
Jenczyk, Jacek
dc.contributor.author
Giussi, Juan Martín
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dc.contributor.author
Jurga, Stefan
dc.contributor.author
Moya, Sergio E.
dc.date.available
2022-10-05T13:57:15Z
dc.date.issued
2020-11
dc.identifier.citation
Martinez Moro, Marta; Jenczyk, Jacek; Giussi, Juan Martín; Jurga, Stefan; Moya, Sergio E.; Kinetics of the thermal response of poly(N-isopropylacrylamide co methacrylic acid) hydrogel microparticles under different environmental stimuli: a time-lapse NMR study; Elsevier; Journal of Colloid and Interface Science; 580; 11-2020; 439-448
dc.identifier.issn
0021-9797
dc.identifier.uri
http://hdl.handle.net/11336/171942
dc.description.abstract
Hypothesis: Hydrogels of N-isopropylacrylamide and methacrylic acid (P(NIPAm-co-MAA)) display pH sensitivity and complex positively charged molecules through carboxylate groups, while having a critical solution temperature at which they reduce in volume and dehydrate. We aimed to elucidate how the responsiveness of MAA to environmental changes alters PNIPAm hydrogels at the molecular level using nuclear magnetic resonance (NMR). Time-lapse NMR allows us to follow the evolution of NMR signal under a temperature stimulus, providing unique information on conformational freedom of the hydrogel polymers. Experiments: We used time-lapse NMR to follow the evolution of the NMR signal with time over a temperature change from 25 to 40 °C and to study the swelling/deswelling kinetics of P(NIPAm-co-MAA) microgels at different pH values and ionic strengths, and in the presence of positively charged molecules complexing carboxylate groups. Findings: At acid pH, hydrogel collapse is favored over neutral pH, and at basic pH the carboxylates remain steadily hydrated during temperature increase. Increasing ionic strength results in a faster, more effective collapse than decreasing pH. Complexation of medium-sized molecules with several charges (spermine, spermidine) causes a faster collapse than complexation with large molecular weight poly(allylamine) hydrochloride, but similar to the collapse effected by large poly(diallyldimethylammonium) chloride. This work opens new perspectives to using time-lapse NMR to study thermoresponsive systems that respond to multiple stimuli, with particular relevance in designing hydrogels for drug delivery.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
DESWELLING KINETICS
dc.subject
HYDROGEL COLLAPSE
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NIPAM-MAA MICROGELS
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POLYAMINES
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TIME-LAPSE NMR
dc.subject.classification
Físico-Química, Ciencia de los Polímeros, Electroquímica
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dc.subject.classification
Ciencias Químicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Kinetics of the thermal response of poly(N-isopropylacrylamide co methacrylic acid) hydrogel microparticles under different environmental stimuli: a time-lapse NMR study
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-10-03T17:55:46Z
dc.journal.volume
580
dc.journal.pagination
439-448
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Martinez Moro, Marta. Basque Research and Technology Alliance; España
dc.description.fil
Fil: Jenczyk, Jacek. Adam Mickiewicz University; Polonia
dc.description.fil
Fil: Giussi, Juan Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
dc.description.fil
Fil: Jurga, Stefan. Adam Mickiewicz University; Polonia
dc.description.fil
Fil: Moya, Sergio E.. Basque Research and Technology Alliance; España
dc.journal.title
Journal of Colloid and Interface Science
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0021979720309279
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jcis.2020.07.049
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