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dc.contributor.author
Castillo, Natalia Alejandra
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dc.contributor.author
Perdigón, Gabriela del Valle
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dc.contributor.author
de Moreno, Maria Alejandra
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dc.date.available
2017-05-31T18:24:53Z
dc.date.issued
2011-08
dc.identifier.citation
Castillo, Natalia Alejandra; Perdigón, Gabriela del Valle; de Moreno, Maria Alejandra; Oral administration of a probiotic Lactobacillus modulates cytokine production and TLR expression improving the immune response against Salmonella enterica serovar Typhimurium infection in mice; Biomed Central; Bmc Microbiology; 11; 177; 8-2011; 1-12
dc.identifier.issn
1471-2180
dc.identifier.uri
http://hdl.handle.net/11336/17173
dc.description.abstract
Background: Diarrheal infections caused by Salmonella, are one of the major causes of childhood morbidity and mortality in developing countries. Salmonella causes various diseases that range from mild gastroenteritis to enteric fever, depending on the serovar involved, infective dose, species, age and immune status of the host. Probiotics are proposed as an attractive alternative possibility in the prevention against this pathogen infection. Previously we demonstrated that continuous Lactobacillus casei CRL 431 administration to BALB/c mice before and after challenge with Salmonella enterica serovar Typhimurium (S. Typhimurium) decreased the severity of Salmonella infection. The aim of the present work was to deep into the knowledge about how this probiotic bacterium exerts its effect, by assessing its impact on the expression and secretion of pro-inflammatory (TNFa, IFNg) and anti- inflammatory (IL-10) cytokines in the inductor and effector sites of the gut immune response, and analyzing toll- like receptor (TLR2, TLR4, TLR5 and TLR9) expressions in both healthy and infected mice.
Results: Probiotic administration to healthy mice increased the expression of TLR2, TLR4 and TLR9 and improved the production and secretion of TNFa, IFNg and IL-10 in the inductor sites of the gut immune response (Peyer’s patches). Post infection, the continuous probiotic administration, before and after Salmonella challenge, protected the host by modulating the inflammatory response, mainly in the immune effector site of the gut, decreasing TNFa and increasing IFNg, IL-6 and IL-10 production in the lamina propria of the small intestine.
Conclusions: The oral administration of L. casei CRL 431 induces variations in the cytokine profile and in the TLRs expression previous and also after the challenge with S. Typhimurium. These changes show some of the immune mechanisms implicated in the protective effect of this probiotic strain against S. Typhimurium, providing an alternative way to reduce the severity of the infection.

dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Biomed Central
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
L. Casei Crl 431
dc.subject
Salmonella
dc.subject
Immune Mechanisms
dc.subject
Mucosal Immunity
dc.subject.classification
Inmunología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Oral administration of a probiotic Lactobacillus modulates cytokine production and TLR expression improving the immune response against Salmonella enterica serovar Typhimurium infection in mice
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-02-05T14:59:26Z
dc.journal.volume
11
dc.journal.number
177
dc.journal.pagination
1-12
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Castillo, Natalia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); Argentina
dc.description.fil
Fil: Perdigón, Gabriela del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); Argentina
dc.description.fil
Fil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
dc.journal.title
Bmc Microbiology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.biomedcentral.com/1471-2180/11/177
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1186/1471-2180-11-177
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