Artículo
The Parkinson disease pain classification system: Results from an international mechanism-based classification approach
Mylius, Veit; Perez Lloret, Santiago
; Cury, Rubens G.; Teixeira, Manoel J.; Barbosa, Victor R.; Barbosa, Egberto R.; Moreira, Larissa I.; Listik, Clarice; Fernandes, Ana M.; de Lacerda Veiga, Diogo; Barbour, Julio; Hollenstein, Nathalie; Oechsner, Matthias; Walch, Julia; Brugger, Florian; Hägele Link, Stefan; Beer, Serafin; Rizos, Alexandra; Chaudhuri, Kallol Ray; Bouhassira, Didier; Lefaucheur, Jean Pascal; Timmermann, Lars; Gonzenbach, Roman; Kägi, Georg; Möller, Jens Carsten; Ciampi de Andrade, Daniel
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Fecha de publicación:
04/2021
Editorial:
Lippincott Williams
Revista:
Pain
ISSN:
0304-3959
e-ISSN:
1872-6623
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Pain is a common nonmotor symptom in patients with Parkinson disease (PD) but the correct diagnosis of the respective cause remains difficult because suitable tools are lacking, so far. We developed a framework to differentiate PD- from non-PD-related pain and classify PD-related pain into 3 groups based on validated mechanistic pain descriptors (nociceptive, neuropathic, or nociplastic), which encompass all the previously described PD pain types. Severity of PD-related pain syndromes was scored by ratings of intensity, frequency, and interference with daily living activities. The PD-Pain Classification System (PD-PCS) was compared with classic pain measures (ie, brief pain inventory and McGill pain questionnaire [MPQ], PDQ-8 quality of life score, MDS-UPDRS scores, and nonmotor symptoms). 159 nondemented PD patients (disease duration 10.2 6 7.6 years) and 37 healthy controls were recruited in 4 centers. PDrelated pain was present in 122 patients (77%), with 24 (15%) suffering one or more syndromes at the same time. PD-related nociceptive, neuropathic, or nociplastic pain was diagnosed in 87 (55%), 25 (16%), or 35 (22%), respectively. Pain unrelated to PD was present in 35 (22%) patients. Overall, PD-PCS severity score significantly correlated with pain’s Brief Pain Inventory and MPQ ratings, presence of dyskinesia and motor fluctuations, PDQ-8 scores, depression, and anxiety measures. Moderate intrarater and interrater reliability was observed. The PD-PCS is a valid and reliable tool for differentiating PD-related pain from PD-unrelated pain. It detects and scores mechanistic pain subtypes in a pragmatic and treatment-oriented approach, unifying previous classifications of PD-pain.
Palabras clave:
Parkinson's Disease
,
Pain
,
Clinical rating scale
,
Validation
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Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Mylius, Veit; Perez Lloret, Santiago; Cury, Rubens G.; Teixeira, Manoel J.; Barbosa, Victor R.; et al.; The Parkinson disease pain classification system: Results from an international mechanism-based classification approach; Lippincott Williams; Pain; 162; 4; 4-2021; 1201-1210
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