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dc.contributor.author
Perez Lloret, Santiago
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dc.contributor.author
Merello, Marcelo Jorge
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dc.date.available
2017-05-22T20:07:40Z
dc.date.issued
2014-03
dc.identifier.citation
Perez Lloret, Santiago; Merello, Marcelo Jorge; Two new adenosine receptor antagonists for the treatment of Parkinson's disease: istradefylline versus tozadenant; Taylor & Francis; Expert Opinion On Pharmacotherapy; 15; 8; 3-2014; 1097-1107
dc.identifier.issn
1465-6566
dc.identifier.uri
http://hdl.handle.net/11336/16826
dc.description.abstract
INTRODUCTION: Adenosine A2A receptors are localized in the brain, mainly within the caudate and putamen nuclei of the basal ganglia. Their activation leads to stimulation of the 'indirect' pathway. Conversely, administration of A2A receptor antagonists leads to inhibition of this pathway, which was translated into reduced hypomotility in several animal models of parkinsonism. AREAS COVERED: In this review, the effects of two A2A receptor antagonists, istradefylline and tozadenant, on parkinsonian symptoms in animal and humans will be discussed. EXPERT OPINION: Animal studies have shown potent antiparkinsonian effects for several A2A receptor antagonists, including istradefylline. In clinical trials, istradefylline reduced OFF time when administered with levodopa, but results are inconclusive. Results with tozadenant are scarce. Modification of thalamic blood flow compatible with reduced inhibition was noted in one small trial, followed by a significant reduction in OFF time in a larger one. Therefore, both drugs show promising efficacy for the reduction of OFF time in levodopa-treated Parkinson's disease patients, but further research is needed in order to obtain definitive conclusions.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Taylor & Francis
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
A2a Receptor Antagonists
dc.subject
Adenosine
dc.subject
Motor Fluctuations
dc.subject
Wearing-Off
dc.subject.classification
Farmacología y Farmacia
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Two new adenosine receptor antagonists for the treatment of Parkinson's disease: istradefylline versus tozadenant
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-05-19T18:14:58Z
dc.identifier.eissn
1744-7666
dc.journal.volume
15
dc.journal.number
8
dc.journal.pagination
1097-1107
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Perez Lloret, Santiago. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas "Raúl Carrea"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Merello, Marcelo Jorge. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia. Instituto de Investigaciones Neurológicas "Raúl Carrea"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Expert Opinion On Pharmacotherapy
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.1517/14656566.2014.903924?journalCode=ieop20
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1517/14656566.2014.903924
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