Artículo
Optimal control strategies to tailor antivirals for acute infectious diseases in the host
Perez, Mara Isabel
; Abuin, Pablo
; Actis, Marcelo Jesús
; Ferramosca, Antonio
; Hernandez Vargas, Esteban Abelardo; González, Alejandro Hernán
Fecha de publicación:
06/2021
Editorial:
Cornell University
Revista:
ArXiv.org
ISSN:
2331-8422
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Several mathematical models in SARS-CoV-2 have shown how target-cell model can help to understand the spread of the virus in the host and how potential candidates of antiviral treatments can help to control the virus. Concepts as equilibrium and stability show to be crucial to qualitative determine the best alternatives to schedule drugs, according to effectivity in inhibiting the virus infection and replication rates. Important biological events such as rebounds of the infections (when antivirals are incorrectly interrupted) can also be explained by means of a dynamic study of the target-cell model. In this work a full characterization of the dynamical behavior of the target-cell models under control actions is made and, based on this characterization, the optimal fixeddose antiviral schedule that produces the smallest amount of dead cells (without viral load rebounds) is computed. Several simulation results - performed by considering real patient data - show the potential benefits of both, the model characterization and the control strategy.
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Articulos(CCT - SANTA FE)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - SANTA FE
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - SANTA FE
Articulos(INTEC)
Articulos de INST.DE DES.TECNOL.PARA LA IND.QUIMICA (I)
Articulos de INST.DE DES.TECNOL.PARA LA IND.QUIMICA (I)
Citación
Perez, Mara Isabel; Abuin, Pablo; Actis, Marcelo Jesús; Ferramosca, Antonio; Hernandez Vargas, Esteban Abelardo; et al.; Optimal control strategies to tailor antivirals for acute infectious diseases in the host; Cornell University; ArXiv.org; 6-2021; 1-26
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