Artículo
Interleukin-17 mediated immunity during infections with Trypanosoma cruzi and other protozoans
Amezcua Vesely, Maria Carolina
; Rodriguez, Constanza
; Gruppi, Adriana
; Acosta Rodriguez, Eva Virginia
Fecha de publicación:
05/2020
Editorial:
Elsevier Science
Revista:
Biochimica et Biophysica Acta - Molecular Basis of Disease
ISSN:
0925-4439
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Host resistance during infection with Trypanosoma cruzi, and other protozoans, is dependent on a balanced immune response. Robust immunity against these pathogens requires of the concerted action of many innate and adaptive cell populations including macrophages, neutrophils, dendritic cells, CD4+, and CD8+ T cells and B cells among others. Indeed, during most protozoan infections only a balanced production of inflammatory (TH1) and anti-inflammatory (TH2/regulatory) cytokines will allow the control of parasite spreading without compromising host tissue integrity. The description of TH17 cells, a novel effector helper T cell lineage that produced IL-17 as signature cytokine, prompted the revision of our knowledge about the mechanisms that mediate protection and immunopathology during protozoan infections. In this manuscript we discuss the general features of IL-17 mediated immune responses as well as the cellular sources, effector mechanisms and overall role of IL-17 in the immune response to T. cruzi and other protozoan infections.
Palabras clave:
TRYPANOSOMA CRUZI
,
IL-17
,
CHAGAS' DISEASE
,
PROTOZOAN INFECTIONS
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Colecciones
Articulos(CIBICI)
Articulos de CENTRO DE INV.EN BIOQUI.CLINICA E INMUNOLOGIA
Articulos de CENTRO DE INV.EN BIOQUI.CLINICA E INMUNOLOGIA
Citación
Amezcua Vesely, Maria Carolina; Rodriguez, Constanza; Gruppi, Adriana; Acosta Rodriguez, Eva Virginia; Interleukin-17 mediated immunity during infections with Trypanosoma cruzi and other protozoans; Elsevier Science; Biochimica et Biophysica Acta - Molecular Basis of Disease; 1866; 5; 5-2020; 1-12
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