Artículo

Antiproliferative activity of withanolides against human breast cancer cell lines

Machín, Rubén; Veleiro, Adriana SilviaIcon ; Nicotra, Viviana EstelaIcon ; Oberti, Juan Carlos MaríaIcon ; Padrón, José
Fecha de publicación: 05/2010
Editorial: American Chemical Society
Revista: Journal Of Natural Products
ISSN: 0163-3864
1520-6025
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

The in vitro antiproliferative activity of a series of 22 naturally occurring withanolides was examined against the T-47D, MCF7, MCF7/BUS, MDA-MB-231, and SK-Br-3 human solid tumor breast cancer cell lines. The most active compound showed GI(50) values in the range 0.16-0.71 muM. The aromatic withanolide 19 exhibited specific activity for the estrogen-receptor-positive cell lines (T-47D, MCF7, and MCF7/BUS). Overall, the results demonstrated the relevance of the substitution pattern on the A and B rings on the resultant antiproliferative activity.
Palabras clave: Withanolides , Solanaceae , Antiproliferative Activity
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/15769
URL: http://pubs.acs.org/doi/abs/10.1021/np9006734
DOI: https://doi.org/10.1021/np9006734
Colecciones
Articulos(IMBIV)
Articulos de INST.MULTIDISCIPL.DE BIOLOGIA VEGETAL (P)
Citación
Machín, Rubén; Veleiro, Adriana Silvia; Nicotra, Viviana Estela; Oberti, Juan Carlos María; Padrón, José; Antiproliferative activity of withanolides against human breast cancer cell lines; American Chemical Society; Journal Of Natural Products; 73; 5; 5-2010; 966-968
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